Research for the development of medical treatment of adenoviral ocular infection and its introduction in clinical practice
Project/Area Number |
15K10911
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Ophthalmology
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Research Institution | Fukuoka University |
Principal Investigator |
Uchio Eiichi 福岡大学, 医学部, 教授 (70232840)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | アデノウイルス / 抗ウイルス薬 / 遺伝子系統解析 / 流行性角結膜炎 / 結膜炎 / レセプター / 消毒薬 / 治療 |
Outline of Final Research Achievements |
Adenovirus causes epidemic keratoconjunctivitis and it has induced large epidemic every year. New types have appeared recently, and ocular manifestations have changed. Antiviral activity of stavudine was evaluated in several types in vitro. It was shown that stavudine had dose-dependent inhibitory effect on novel types 53, 54 and 56 similarly with type 4 and 64 of conventional types indicating that stavudine is effective against novel adenovirus types that are currently causing epidemics. From the clinical analysis of adenoviral conjunctivitis caused by type 54, it was shown that clinical score of younger cases was significantly more serious than that of adult cases, indicating age specific clinical characteristics leading to clinical insight.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Japanese guidelines for allergic conjunctival diseases 20172017
Author(s)
Takamura E, Uchio E, Ebihara N, Ohno S, Ohashi Y, Okamoto S, Kumagai N, Satake Y, Shoji J, Nakagawa Y, Namba K, Fukagawa K, Fukushima A, Fujishima H,The Japanese Society of Allergology.
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Journal Title
Allergology International
Volume: 66
Issue: 2
Pages: 220-229
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed / Open Access
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[Journal Article] Steroid-Sparing Effect of 0.1% Tacrolimus Eye Drop for Treatment of Shield Ulcer and Corneal Epitheliopathy in Refractory Allergic Ocular Diseases2017
Author(s)
Miyazaki D, Fukushima A, Ohashi Y, Ebihara N, Uchio E, Okamoto S, Shoji J, Takamura E, Nakagawa Y, Namba K, Fujishima H.
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Journal Title
Ophthalmology
Volume: 124
Issue: 3
Pages: 287-294
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Correlation between acute conjunctivitis and Asian dust on ocular surfaces2016
Author(s)
Ko R, Hayashi M, Hayashi H, Hayashi K, Kato H, Kurata Y, Fuchino Y, Nakamichi T, Migita H, Yano H, Sakata T, Uchio E
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Journal Title
J Toxicol Environ Health A
Volume: 79
Issue: 8
Pages: 367-375
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Steroid sparing effect of 0.1% tacrolimus eye drops for treatment of shield ulcer and corneal epitheliopathy in refractory allergic ocular diseases2016
Author(s)
Miyazaki D, Fukushima A, Ohashi Y, Ebihara N, Uchio E, Okamoto S, Shoji J, Takamura E, Nakagawa Y, Namba K, Fujishima H
Organizer
86th ARVO
Place of Presentation
Seattle
Year and Date
2016-05-01
Related Report
Int'l Joint Research
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