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The serum concentration of SEMA4A in eye diseases

Research Project

Project/Area Number 15K10912
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionKyushu University (2016-2017)
Fukuoka University (2015)

Principal Investigator

Yukio Sassa  九州大学, 医学研究院, 共同研究員 (80580315)

Co-Investigator(Kenkyū-buntansha) 奥野 龍禎  大阪大学, 医学系研究科, 助教 (00464248)
石橋 達朗  九州大学, 大学病院, 病院長 (30150428)
向野 利寛  福岡大学, 医学部, 教授 (40117106)
福島 修一郎  大阪大学, 基礎工学研究科, 助教 (40362644)
吉田 茂生  九州大学, 大学病院, 助手 (50363370)
安井 武史  徳島大学, 大学院社会産業理工学研究部(理工学域), 教授 (70314408)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsSEMA4A / 視神経炎 / 炎症性眼疾患 / SHG顕微鏡 / 網膜下線維化 / 血管新生モデル / 血清濃度 / 硝子体濃度 / 原田病
Outline of Final Research Achievements

We evaluated the serum concentrations of SEMA4A in eye diseases. The average serum concentration of SEMA4A in all patients evaluated was 3702+/-8583U/ml(n=248). In the optic neuritis patients, SEMA4A might be higher than other diseases(5746+/12390U/ml, n=12). SEMA4A might also be higher in patients with Vogt-Koyanagi-Harada disease.(12502+/-11202U/ml, n=5). The vitreous concentration of SEMA4A was much lower compared with the serum concentration( 232+/-95.6U/ml n=12).SEMA4A might play a role on progressing these eye diseases but might not be useful as a specific biomarker.The further study must be needed to clarify these results because of the small sample number.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (9 results)

All 2018 2016 2015

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 7 results,  Acknowledgement Compliant: 3 results,  Open Access: 5 results) Presentation (2 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] The kinetics of VEGF and MCP-1 in the second vitrectomy cases with proliferative diabetic retinopathy.2016

    • Author(s)
      Sassa Y,Yoshida S, Ishikawa K, Asato R, Ishibashi T, Kono T
    • Journal Title

      Eye (Lond).

      Volume: 30 Pages: 746-53

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Tenascin-C promotes angiogenesis in fibrovascular membranes in eyes with proliferative diabetic retinopathy.2016

    • Author(s)
      Kobayashi Y,Yoshida S, Zhou Y, Nakama T, Ishikawa K, Arima M, Nakao S, Sassa Y, Takeda A, Hisatomi T, Ikeda Y, Matsuda A,
    • Journal Title

      Mol Vis.

      Volume: 30 Pages: 436-45

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The Kinetics of VEGF and MCP-1 in the Second Vitrectomy Cases with Proliferative Diabetic Retinopathy.2016

    • Author(s)
      Yukio Sassa, Shigeo Yoshida, Keijiro Ishikawa, Ryo Asato, Tatsuro Ishibashi and Toshihiro Kono
    • Journal Title

      Eye

      Volume: in press

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Overexpression of CD163 in vitreous and fibrovascular membranes of patients with proliferative diabetic retinopathy: possible involvement of periostin.2015

    • Author(s)
      Kobayashi Y, Yoshida S, Nakama T, Zhou Y, Ishikawa K, Arita R, Nakao S, Miyazaki M, Sassa Y, Oshima Y, Izuhara K, Kono T, Ishibashi T
    • Journal Title

      Br J Ophthalmol.

      Volume: 99(4) Pages: 451-456

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased Expression of M-CSF and IL-13 in Vitreous of Patients with Proliferative Diabetic Retinopathy: Implications for M2 Macrophage-involving Fibrovascular Membrane Formation2015

    • Author(s)
      Shigeo Yoshida, Yoshiyuki Kobayashi, Takahito Nakama, Yedi Zhou, Keijiro Ishikawa, Ryoichi Arita, Shintaro Nakao, Masanori Miyazaki, Yukio Sassa, Yuji Oshima, Kenji Izuhara, Toshihiro Kono, and Tatsuro Ishibashi
    • Journal Title

      Br J Ophthalmol.

      Volume: 99(5) Pages: 629-634

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased vitreous concentrations of MCP-1 and IL-6 after vitrectomy in patients with proliferative diabetic retinopathy: Possible relation to postoperative macular edema2015

    • Author(s)
      Kubo Y, Kobayashi Y, Zhou Y, Nakama T, Yamaguchi M, Tachibana T, Ishikawa K, Arita R, Nakao S, Sassa Y, Oshima Y, Kono T, Ishibashi T.
    • Journal Title

      Br J Ophthalmol.

      Volume: 99(7) Pages: 960-966

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 増殖糖尿病網膜症に対する硝子体手術10年後視力予後因子の統計学的検討―増殖糖尿病網膜症長期視力予後因子―2015

    • Author(s)
      佐々 由季生、秋山 雅人、吉田 茂生、佐伯 有祐、高橋 理恵、光武 智子、向野 利寛
    • Journal Title

      臨床眼科

      Volume: 69(8) Pages: 1269-1275

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 失明原因第2位!知っておきたい糖尿病網膜症2018

    • Author(s)
      佐々 由季生
    • Organizer
      浜の町病院市民公開講座
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Ten-year visual outcome following vitreous surgery for proliferative diabetic retinopathy2015

    • Author(s)
      Yukio Sassa, Shigeo Yoshida, Masato Akiyama, Yusuke Saeki, Rie Takahashi, Tatsuro Ishibashi, Toshihiro Kono
    • Organizer
      The 8th Joint Meeting of Korea-China-Japan
    • Place of Presentation
      福岡市
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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