| Project/Area Number |
15K10912
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kyushu University (2016-2017)
Fukuoka University (2015) |
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Principal Investigator |
Yukio Sassa 九州大学, 医学研究院, 共同研究員 (80580315)
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| Co-Investigator(Kenkyū-buntansha) |
奥野 龍禎 大阪大学, 医学系研究科, 助教 (00464248)
石橋 達朗 九州大学, 大学病院, 病院長 (30150428)
向野 利寛 福岡大学, 医学部, 教授 (40117106)
福島 修一郎 大阪大学, 基礎工学研究科, 助教 (40362644)
吉田 茂生 九州大学, 大学病院, 助手 (50363370)
安井 武史 徳島大学, 大学院社会産業理工学研究部(理工学域), 教授 (70314408)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | SEMA4A / 視神経炎 / 炎症性眼疾患 / SHG顕微鏡 / 網膜下線維化 / 血管新生モデル / 血清濃度 / 硝子体濃度 / 原田病 |
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| Outline of Final Research Achievements |
We evaluated the serum concentrations of SEMA4A in eye diseases. The average serum concentration of SEMA4A in all patients evaluated was 3702+/-8583U/ｍl(n=248). In the optic neuritis patients, SEMA4A might be higher than other diseases(5746+/12390U/ml, n=12). SEMA4A might also be higher in patients with Vogt-Koyanagi-Harada disease.(12502+/-11202U/ml, n=5). The vitreous concentration of SEMA4A was much lower compared with the serum concentration( 232+/-95.6U/ml n=12).SEMA4A might play a role on progressing these eye diseases but might not be useful as a specific biomarker.The further study must be needed to clarify these results because of the small sample number.
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