| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
We are developing transplantation therapy of ES/iPS-derived retinas in end-stage retinal degeneration. We have observed a possibility that remaining inner neurons including bipolar cells in the graft could sometimes interfere with the synapse formation between the host bipolar cells and graft photoreceptors. Yet, these graft inner cells are also important for graft photoreceptors to functionally mature, so we produced genetically engineered graft retina in which graft inner or bipolar cells would degenerate at around the timing of synaptogenesis. By producing such iPS/ES-retina by deleting some gene involved in bipolar cell maturation, we could obtain a promising results suggestive of better synapse formation and visual function.
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