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Causative Gene of Chronic Intestinal Pseudo-obstruction

Research Project

Project/Area Number 15K10918
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatric surgery
Research InstitutionChiba University

Principal Investigator

Terui Keita  千葉大学, 医学部附属病院, 講師 (70375773)

Co-Investigator(Kenkyū-buntansha) 羽田 明  千葉大学, 大学院医学研究院, 教授 (00244541)
吉田 英生  千葉大学, 大学院医学研究院, 教授 (60210712)
Co-Investigator(Renkei-kenkyūsha) SEKINE Akihiro  千葉大学, 予防医学センター, 教授 (30425631)
TAKEMURA Ryou  千葉大学, 医学部附属病院, 特任助教 (50747516)
MASHIMO Youichi  千葉大学, 大学院医学研究院, 技術職員 (90422253)
SAITOU Takeshi  千葉大学, 大学院医学研究院, 准教授 (20406044)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords慢性特発性偽性腸閉塞症 / 次世代シーケンサー
Outline of Final Research Achievements

Chronic Intestinal Pseudo-obstruction (CIIP) is infantile disease presenting progressive ileus. We care rare family cases of CIIP with same symptom.
We tried to find causative gene by using next generation sequencer. However, we could not because of low quality DNA sample of one of the families.
ACTG2 (Enteric smooth muscle actin γ-2),MYH11 (myosin heavy chain 11) were thought to be causative gene of CIIP. But, there was no abnormal gene in this family cases.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2017

All Presentation (2 results)

  • [Presentation] 次世代シーケンサーを用いた慢性特発性偽性腸閉塞症の原因遺伝子探索2017

    • Author(s)
      照井慶太
    • Organizer
      第54回日本小児外科学会学術集会
    • Place of Presentation
      仙台国際センター(宮城県・仙台)
    • Year and Date
      2017-05-11
    • Related Report
      2016 Research-status Report
  • [Presentation] 次世代シーケンサーを用いた慢性特発性偽性腸閉塞症の原因遺伝子探索2017

    • Author(s)
      照井慶太,関根章博,山下泰生,北原輝栄,竹村亮,真下陽一,齋藤武,中田光政,小松秀吾,羽田明,吉田英生
    • Organizer
      第54回日本小児外科学会学術集会
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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