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Development of an innovative surgical simulation /navigation system for neuroblastoma

Research Project

Project/Area Number 15K10924
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatric surgery
Research InstitutionKyushu University

Principal Investigator

Souzaki Ryota  九州大学, 医学研究院, 講師 (10403990)

Co-Investigator(Kenkyū-buntansha) 家入 里志  鹿児島大学, 医歯学域医学系, 教授 (00363359)
植村 宗則  九州大学, ARO次世代医療センター, 特任助教 (50636157)
木下 義晶  九州大学, 大学病院, 准教授 (80345529)
小幡 聡  九州大学, 大学病院, 助教 (30710975)
神保 教広  九州大学, 大学病院, 共同研究員 (10650559)
田口 智章  九州大学, 医学研究院, 教授 (20197247)
橋爪 誠  九州大学, 医学研究院, 教授 (90198664)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords神経芽腫 / 手術シミュレーション / 立体臓器モデル / 手術ナビゲーション / ナビゲーション手術
Outline of Final Research Achievements

For the adrenal gland neuroblastoma, a three-dimensional organ model was created from a preoperative photographed CT image using a 3D printer. Using a resin that can be inserted into a trocar, a body was created, and it was used for simulation of tumor position in laparoscopic view, and examination of the best position of the trocar. We also modeled adrenal gland and liver model for liver metastasis cases of neuroblastoma and conducted surgical simulation.
For hepatoblastoma, the same pediatric malignant tumor as neuroblastoma, a three-dimensional organ model was created from preoperative CT images. We confirmed the positional relationship between the portal vein and the hepatic vein and the position of the tumor, and simulated the resection line before surgery. We found the utility such as being able to more easily understand the anatomical information.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (18 results)

All 2017 2016 2015

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (9 results) (of which Int'l Joint Research: 4 results,  Invited: 2 results)

  • [Journal Article] Inflammatory myofibroblastic tumors of the lung carrying a chimeric A2M-ALK gene: report of 2 infantile cases and review of the differential diagnosis of infantile pulmonary lesions2017

    • Author(s)
      Tanaka Mio、Kohashi Kenichi、Kushitani Kei、Yoshida Misa、Kurihara Sho、Kawashima Masumi、Ueda Yuka、Souzaki Ryota、Kinoshita Yoshiaki、Oda Yoshinao、Takeshima Yukio、Hiyama Eiso、Taguchi Tomoaki、Tanaka Yukichi
    • Journal Title

      Human Pathology

      Volume: 66 Pages: 177-182

    • DOI

      10.1016/j.humpath.2017.06.013

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuronal leucine-rich repeat 1 negatively regulates anaplastic lymphoma kinase in neuroblastoma.2016

    • Author(s)
      Satoh S, Takatori A, Ogura A, Kohashi K, Souzaki R, Kinoshita Y, Taguchi T, Hossain MS, Ohira M, Nakamura Y, Nakagawara A.
    • Journal Title

      Sci Rep.

      Volume: 6 Pages: 32682-32682

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Preoperative simulation regarding the appropriate port location for laparoscopic hepaticojejunostomy: a randomized study using a disease-specific training simulator.2016

    • Author(s)
      Jimbo T, Ieiri S, Obata S, Uemura M, Souzaki R, Matsuoka N, Katayama T, Masumoto K, Hashizume M, Taguchi T.
    • Journal Title

      Pediatr Surg Int.

      Volume: 32 Pages: 901-7

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Virtually transparent surgical instruments in endoscopic surgery with augmentation of obscured regions.2016

    • Author(s)
      Koreeda Y, Kobayashi Y, Ieiri S, Nishio Y, Kawamura K, Obata S, Souzaki R, Hashizume M, Fujie MG.
    • Journal Title

      Int J Comput Assist Radiol Surg.

      Volume: 11 Pages: 1927-36

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Preoperative surgical simulation of laparoscopic adrenalectomy for neuroblastoma using a three-dimensional printed model based on preoperative CT images.2015

    • Author(s)
      Souzaki R, Kinoshita Y, Ieiri S , Kawakubo N, Obata S, Jimbo T, Koga Y, Hashizume M, Taguchi T.
    • Journal Title

      J Pediatr Surg.

      Volume: 50 Issue: 12 Pages: 2112-2112

    • DOI

      10.1016/j.jpedsurg.2015.08.037

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Three-dimensional liver model based on preoperative CT images as a tool to assist in surgical planning for hepatoblastoma in a child.2015

    • Author(s)
      Souzaki R, Kinoshita Y, Ieiri S, Hayashida M, Koga Y, Shirabe K, Hara T, Maehara Y, Hashizume M, Taguchi T.
    • Journal Title

      Pediatr Surg Int.

      Volume: 31 Issue: 6 Pages: 593-593

    • DOI

      10.1007/s00383-015-3709-9

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Validity of image-defined risk factors in localized neuroblastoma: A report from two centers in Western Japan.2015

    • Author(s)
      Fumino S, Kimura K, Iehara T, Nishimura M, Nakamura S, Souzaki R, Nishie A, Taguchi T, Hosoi H, Tajiri T.
    • Journal Title

      J Pediatr Surg.

      Volume: 50 Issue: 12 Pages: 2102-2102

    • DOI

      10.1016/j.jpedsurg.2015.08.039

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Validity of HB-EGF as Target for Human Neuroblastoma Therapy.2015

    • Author(s)
      Nam SO, Yotsumoto F, Miyata K, Souzaki R, Taguchi T, Kuroki M, Miyamoto S.
    • Journal Title

      Anticancer Res.

      Volume: 35 Pages: 4433-4433

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Glypican 3 Expression in Pediatric Malignant Solid Tumors.2015

    • Author(s)
      Kinoshita Y, Tanaka S, Souzaki R, Miyoshi K, Kohashi K, Oda Y, Nakatsura T, Taguchi T.
    • Journal Title

      Eur J Pediatr Surg.

      Volume: 25 Issue: 01 Pages: 138-44

    • DOI

      10.1055/s-0034-1393961

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 小児固形腫瘍に対する3Dモデルを用いた手術シミュレーションとリアルタイムナビゲーション手術2016

    • Author(s)
      宗﨑良太、小幡 聡、神保教広、木下義晶、植村宗則、古賀友紀、孝橋賢一、小田義直、橋爪 誠、田口智章
    • Organizer
      第28回日本内視鏡外科学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2016-12-10
    • Related Report
      2015 Research-status Report
  • [Presentation] Laparoscopic surgery for neuroblastoma in children treated at a single institution2016

    • Author(s)
      Ryota Souzaki, Yoshiaki Kinoshita, Makoto Hashizume, Tomoaki Taguchi
    • Organizer
      第57回日本小児血液・がん学会
    • Place of Presentation
      山梨
    • Year and Date
      2016-11-27
    • Related Report
      2015 Research-status Report
  • [Presentation] 新生児肝血管腫の3例2016

    • Author(s)
      宗崎良太、木下義晶、林田真、三島泰彦、飯田則利、橋爪誠、田口智章
    • Organizer
      第31回日本小児学会秋季シンポジウム
    • Place of Presentation
      熊本
    • Year and Date
      2016-10-31
    • Related Report
      2015 Research-status Report
  • [Presentation] Efficacy of three-Dimensional printing Model based on preoperative CT images for the surgery of pediatric malignancies2016

    • Author(s)
      Ryota Souzaki, Yoshiaki Kinoshita, Satoshi Ieiri, Naonori Kawakubo, Takahiro Jimbo, Satoshi Obata, Yuhki Koga, Kina Miyoshi, Kenichi Kohashi, Yoshinao Oda, Toshiro Hara, Makoto Hashizume, Tomoaki Taguchi
    • Organizer
      The 47th Congress of the International Society of Paediatric oncology (SIOP 2015)
    • Place of Presentation
      Cape town , South Africa
    • Year and Date
      2016-10-08
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Creating Three-Dimensional full size models based on preoperative CT images for laparoscopic adrenalectomy and liver biopsy in a case demonstrating adrenal neuroblastoma with liver metastasis2016

    • Author(s)
      Ryota Souzaki, Yoshiaki Kinoshita, Naonori Kawakubo, Takahiro Jimbo, Satoshi Obata, Yuhki Koga, Makoto Hashizume, Tomoaki Taguchi
    • Organizer
      ANR
    • Place of Presentation
      Cairns, Australia
    • Year and Date
      2016-06-19
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 新生児副腎部嚢胞性腫瘤の検討2016

    • Author(s)
      宗崎良太、永田公二、家入里志、木下義晶、古賀友紀、三好きな、久田正昭、孝橋賢一、小田義直、原寿郎、橋爪誠、田口智章
    • Organizer
      第52回日本小児外科学会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Clinical outcome of laparoscopic surgery for neuroblastoma in children: A single-institution experience.2016

    • Author(s)
      Ryota Souzaki, Satoshi Obata, Takahiro Jimbo, Yoshiaki Kinoshita, Makoto Hashizume, Tomoaki Taguchi
    • Organizer
      International Pediatric Endosurgery Group
    • Place of Presentation
      Fukuoka
    • Year and Date
      2016-05-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Preoperative surgical simulation for laparoscopic adrenectomy in neuroblastoma using a three-dimensional model based on CT images.2016

    • Author(s)
      Ryota Souzaki, Yoshiaki Kinoshita, Satoshi Ieiri, Naonori Kawakubo, Yuhki Koga, Toshiro Hara, Makoto Hashizume, Tomoaki Taguchi
    • Organizer
      the 48th Annual meeting Pacific Association of Pediatric Surgerons(PAPS)
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2016-05-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 当科における小児腫瘍性病変に対する内視鏡外科手術の適応拡大とその限界2016

    • Author(s)
      宗崎 良太、家入 里志、木下義晶、古賀友紀、三好きな、孝橋賢一、小田義直、原 寿郎、橋爪 誠、田口 智章
    • Organizer
      第115回日本外科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-04-07
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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