The development of fetal therapy for the complete defect type of congenital diaphragmatic hernia using medium-sized animal model
| Project/Area Number |
15K10926
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
FURUKAWA TAIZO 京都府立医科大学, 医学(系)研究科(研究院), 講師 (20515291)
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| Co-Investigator(Kenkyū-buntansha) |
佐和 貞治 京都府立医科大学, 医学(系)研究科(研究院), 教授 (10206013)
木村 修 京都府立医科大学, 医学(系)研究科(研究院), 特任教授 (10315963)
坂井 宏平 京都府立医科大学, 医学(系)研究科(研究院), 助教 (30515292)
田尻 達郎 京都府立医科大学, 医学(系)研究科(研究院), 教授 (80304806)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 小児呼吸器外科学 / 先天性横隔膜ヘルニア / ウサギ / Tracheal occlusion / ボンベシン / 先天性横隔膜ﾍﾙﾆｱ |
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| Outline of Final Research Achievements |
We have investigated the research to create congenital diaphragmatic hernia (CDH) model in the fetal rabbits in order to confirm that Bombesin (BBS), which is one of the neuropeptides, had a positive effect on lung maturity. The CDH model was created artificially by left diaphragmatic incision of the fetal rabbits. The lung maturity in the CDH model with tracheal occlusion (TO) was better than that in the CDH model with no TO. However the lung maturity was not confirmed in the CDH model with BBS. We considered that the one of the reasons was that the optimal dosage of BBS was not still established in this study.
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Report
(4 results)
Research Products
(18 results)
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[Presentation] JNK-STAT3 pathway in neuroblastoma.2016
Author(s)
Higashi M, Sakai K, Fumino S, Aoi S, Furukawa T, Tajiri T
Organizer
40th World Congress of the International College of Surgeons
Place of Presentation
Kyoto
Year and Date
2016-10-24
Related Report
Int'l Joint Research
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[Presentation] Tumor-homing effect of human mesenchymal stem cells in a TH-MYCN mouse model of neuroblastoma.2016
Author(s)
Kimura K, Kishida T, Wakao J, Tanaka T, Higashi M, Fumino S, Aoi S, Furukawa T, Mazda O, Tajiri T
Organizer
49th Annual Meeting of the Pacific Association of Pediatric Surgeons (PAPS)
Place of Presentation
Kauai, USA
Year and Date
2016-05-17
Related Report
Int'l Joint Research
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