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The development of fetal therapy for the complete defect type of congenital diaphragmatic hernia using medium-sized animal model

Research Project

Project/Area Number 15K10926
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatric surgery
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

FURUKAWA TAIZO  京都府立医科大学, 医学(系)研究科(研究院), 講師 (20515291)

Co-Investigator(Kenkyū-buntansha) 佐和 貞治  京都府立医科大学, 医学(系)研究科(研究院), 教授 (10206013)
木村 修  京都府立医科大学, 医学(系)研究科(研究院), 特任教授 (10315963)
坂井 宏平  京都府立医科大学, 医学(系)研究科(研究院), 助教 (30515292)
田尻 達郎  京都府立医科大学, 医学(系)研究科(研究院), 教授 (80304806)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords小児呼吸器外科学 / 先天性横隔膜ヘルニア / ウサギ / Tracheal occlusion / ボンベシン / 先天性横隔膜ヘルニア
Outline of Final Research Achievements

We have investigated the research to create congenital diaphragmatic hernia (CDH) model in the fetal rabbits in order to confirm that Bombesin (BBS), which is one of the neuropeptides, had a positive effect on lung maturity. The CDH model was created artificially by left diaphragmatic incision of the fetal rabbits. The lung maturity in the CDH model with tracheal occlusion (TO) was better than that in the CDH model with no TO. However the lung maturity was not confirmed in the CDH model with BBS. We considered that the one of the reasons was that the optimal dosage of BBS was not still established in this study.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (18 results)

All 2017 2016 2015

All Journal Article (5 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (12 results) (of which Int'l Joint Research: 12 results) Book (1 results)

  • [Journal Article] Surgical intervention and perioperative risk factors of retroperitoneal teratomas in children: a single institution experience.2016

    • Author(s)
      Fumino S, Maniwa J, Takeuchi Y, Sakai K, Higashi M, Aoi S, Furukawa T, Kimura O, Tajiri T
    • Journal Title

      Pediatr Surg Int

      Volume: 32 Issue: 9 Pages: 909-914

    • DOI

      10.1007/s00383-016-3938-6

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tumor-homing effect of human mesenchymal stem cells in a TH-MYCN mouse model of neuroblastoma.2016

    • Author(s)
      Kimura K, Kishida T, Wakao J, Tanaka T, Higashi M, Fumino S, Aoi S, Furukawa T, Mazda O, Tajiri T
    • Journal Title

      J Pediatr Surg

      Volume: 51 Issue: 12 Pages: 2068-2073

    • DOI

      10.1016/j.jpedsurg.2016.09.041

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Surgical intervention strategies for pediatric congenital cystic lesions of the lungs: A 20-year single-institution experience.2015

    • Author(s)
      Furukawa T, Kimura O, Sakai K, Higashi M, Fumino S, Aoi S, Tajiri T
    • Journal Title

      J Pediatr Surg

      Volume: 50 Issue: 12 Pages: 2025-2027

    • DOI

      10.1016/j.jpedsurg.2015.08.019

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Successful Iaparoscopic extirpation of a large omental lipoblastoma in a child.2015

    • Author(s)
      Furukawa T, Aoi S, Sakai K, Higashi M, Fumino S, Tajiri T
    • Journal Title

      Asian J Endosc Surg

      Volume: 9 Issue: 4 Pages: 473-476

    • DOI

      10.1111/ases.12213

    • Related Report
      2015 Research-status Report
  • [Journal Article] 小児の右外頸静脈に発生したvenous aneurysmの一例2015

    • Author(s)
      古川泰三,千葉史子,坂井宏平,樋口恒司,文野誠久,青井重善,木村 修,田尻達郎
    • Journal Title

      日小外会誌

      Volume: 7 Pages: 1205-1209

    • Related Report
      2015 Research-status Report
  • [Presentation] The Direct Conversion of Human Fibroblasts Toward the Myogenic Cell Lineage: The implications of Diaphragmatic Regeneration.2017

    • Author(s)
      Wakao J,Kishida T,Fumino S,Kimura K,Higashi M,Aoi S,Furukawa T,Mazda O,Tajiri T
    • Organizer
      50th Annual Meeting of the Pacific Association of Pediatric Surgeons
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Treatment strategies for different types of lymphangioma. 28-years experience in a single institution.2016

    • Author(s)
      Kimura O, Furukawa T, Fumino S, Aoi S, Tajiri T
    • Organizer
      68th Annual Autum Congress of the Korean Surgical Society
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-11-03
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Retroperitoneal teratomas in children: still challenging for surgeons.2016

    • Author(s)
      Fumino S, Maniwa J, Takeuchi Y, Sakai K, Higashi M, Aoi S, Furukawa T, Kimura O, Tajiri T
    • Organizer
      40th World Congress of the International College of Surgeons
    • Place of Presentation
      Kyoto
    • Year and Date
      2016-10-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] JNK-STAT3 pathway in neuroblastoma.2016

    • Author(s)
      Higashi M, Sakai K, Fumino S, Aoi S, Furukawa T, Tajiri T
    • Organizer
      40th World Congress of the International College of Surgeons
    • Place of Presentation
      Kyoto
    • Year and Date
      2016-10-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Surgical strategy of pediatric epithelial ovarian tumors.2016

    • Author(s)
      Maniwa J, Fumino S, Tanaka T, Sakai K, Higashi M, Aoi S, Furukawa T, Iehara T, Hosoi H, Tajiri T
    • Organizer
      40th World Congress of the International College of Surgeons
    • Place of Presentation
      Kyoto
    • Year and Date
      2016-10-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Perioperative management and surgical intervention for retroperitoneal teratomas in children.2016

    • Author(s)
      Fumino S, Maniwa J, Takeuchi Y, Sakai K, Higashi M, Aoi S, Furukawa T, Kimura O, Tajiri T
    • Organizer
      48th Congress of the International Society of Paediatric Oncology (SIOP)
    • Place of Presentation
      Dublin, Irland
    • Year and Date
      2016-10-19
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Postoperative bowel management for the patients with anorectal malformation associating spinal lesions2016

    • Author(s)
      Aoi S, Furukawa T, Higashi M, Sakai K, Fumino S, Kimura O, Tajiri T
    • Organizer
      A single institute experience. International Children's Continence Society
    • Place of Presentation
      Kyoto
    • Year and Date
      2016-06-30
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Thoracoscopic resection of ectopic mediastinal parathyroid adenoma utilizing gamma probe and intraoperative PTH monitoring in a child.2016

    • Author(s)
      Furukawa T, Fumino S, Sakai K, Higashi M, Aoi S, Tajiri T
    • Organizer
      IPEG’s 25th Annual Congress for Endosurgery in Children
    • Place of Presentation
      Fukuoka
    • Year and Date
      2016-05-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Surgical management and perioperative risk factors of retroperitoneal teratomas in children2016

    • Author(s)
      Fumino S, Maniwa J, Takeuchi Y, Sakai K, Higashi M, Aoi S, Furukawa T, Kimura O, Tajiri T
    • Organizer
      49th Annual Meeting of the Pacific Association of Pediatric Surgeons (PAPS)
    • Place of Presentation
      Kauai, USA
    • Year and Date
      2016-05-17
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] A clinical trial of low-dose mTOR inhibitor therapy for the treatment of children with refractory lymphatic anomaly.2016

    • Author(s)
      Furukawa T, Sakai K, Higashi M, Fumino S, Aoi S, Kimura O, Ozeki M, Tajiri T
    • Organizer
      49th Annual Meeting of the Pacific Association of Pediatric Surgeons (PAPS)
    • Place of Presentation
      Kauai, USA
    • Year and Date
      2016-05-17
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Tumor-homing effect of human mesenchymal stem cells in a TH-MYCN mouse model of neuroblastoma.2016

    • Author(s)
      Kimura K, Kishida T, Wakao J, Tanaka T, Higashi M, Fumino S, Aoi S, Furukawa T, Mazda O, Tajiri T
    • Organizer
      49th Annual Meeting of the Pacific Association of Pediatric Surgeons (PAPS)
    • Place of Presentation
      Kauai, USA
    • Year and Date
      2016-05-17
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Surgical intervention strategies for pediatric congential cystic lesionz of the lungs: A 20-year single-institution experience.2015

    • Author(s)
      Furukawa T
    • Organizer
      48th Annual Meeting of the Pacific Association of Pediatric Surgeons
    • Place of Presentation
      Jeju Island, South Korea.
    • Year and Date
      2015-05-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] 新生児先天性横隔膜ヘルニア(CDH)診療ガイドライン 新生児先天性横隔膜ヘルニア研究グループ編2016

    • Author(s)
      木村 修,古川泰三
    • Total Pages
      114
    • Publisher
      メディカルビュー社
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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