MicroRNA and macrophage dysregulation: role in prolonged inflammation of chronic non-healing wounds
Project/Area Number |
15K10943
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Plastic surgery
|
Research Institution | University of Miyazaki |
Principal Investigator |
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | microRNA / 創傷治癒 / マクロファージ細胞 / MicroRNA / miR-21 / マクロファージ炎症 / 難治性創傷 / マクロファージ |
Outline of Final Research Achievements |
This research project focused on deciphering the role of microRNA and macrophage dysregulation in prolonged inflammation phase of non healing chronic wounds. Employing mouse macrophage cells, we confirmed a set of inflammation-related microRNAs that are dysregulated in hypoxia condition. Among them, miR-21 was profound and induced prolongation of inflammatory phase. miR-21 was found to be necessary for RANKL-induced differentiation of macrophages into osteoclast cells. This function was inhibited by aloin, a derivative of aloe.
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Report
(4 results)
Research Products
(1 results)