MicroRNA and macrophage dysregulation: role in prolonged inflammation of chronic non-healing wounds

Research Project

Project/Area Number	15K10943
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Plastic surgery
Research Institution	University of Miyazaki
Principal Investigator	Madhyastha Radha 宮崎大学, 医学部, 助教 (80381078)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000) Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	microRNA / 創傷治癒 / マクロファージ細胞 / MicroRNA / miR-21 / マクロファージ炎症 / 難治性創傷 / マクロファージ
Outline of Final Research Achievements	This research project focused on deciphering the role of microRNA and macrophage dysregulation in prolonged inflammation phase of non healing chronic wounds. Employing mouse macrophage cells, we confirmed a set of inflammation-related microRNAs that are dysregulated in hypoxia condition. Among them, miR-21 was profound and induced prolongation of inflammatory phase. miR-21 was found to be necessary for RANKL-induced differentiation of macrophages into osteoclast cells. This function was inhibited by aloin, a derivative of aloe.

Report

(4 results)