| Project/Area Number |
15K10955
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
井上 肇 聖マリアンナ医科大学, 医学部, 教授 (60193603)
菅谷 文人 聖マリアンナ医科大学, 医学部, 助教 (70569524)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 表皮細胞 / 乳輪乳頭再生 / 色素細胞 / 培養表皮シート / 乳癌 / 乳房再建 / 移植 / 培養表皮細胞 / 培養色素細胞 / 乳頭乳輪再生 / 混合立体培養 / 再生医療技術 / 培養表皮 / 再生医療 / メラニン / 色素沈着 / 新規キャリア |
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| Outline of Final Research Achievements |
Mammoplasty after mastectomy with breast cancer contributes to patient's QOL improvement, such as reconstruction by implant is insured.However, although the current mammoplasty is possible, the nipple areola reconstruction is invasive of a healthy areola.Therefore, in order to reconstruct this nipple areola, the regeneration of the nipple areola was tried to graft cultured epithelium containing melanocytes by using regenerative medical technology.
In this investigation, a few (1 × 5 mm) skin was collected from the healthy areola, making it possible to prepare a cultured epithelium containing a large amounts of melanocytes. Good engraftment was obtained by grafting this melanocyte rich cultured epithelium to the skin after ablation of the reconstructed breast.When pigmentation was weak, it was possible to improve with such as phototherapy.
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