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Verification and Experimental Study of Acellular Platelet-rich Plasma

Research Project

Project/Area Number 15K10956
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Plastic surgery
Research InstitutionKansai Medical University

Principal Investigator

KUSUMOTO Kenji  関西医科大学, 医学部, 教授 (20161630)

Co-Investigator(Kenkyū-buntansha) 森本 尚樹  関西医科大学, 医学部, 准教授 (40378641)
覚道 奈津子  関西医科大学, 医学部, 講師 (00509490)
光井 俊人  関西医科大学, 医学部, その他 (40449830)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords多血小板血漿 / 無細胞 / 再生医療 / 皮膚潰瘍 / 創傷治癒 / 褥瘡 / シワ治療 / 育毛 / 潰瘍
Outline of Final Research Achievements

Platelet-richi Plasma (PRP) is a plasma included many platelets. Activation of platelets leads to much amount of cytokines. Regenerative medicine applying these cytokines is started in clinical fields. This PRP therapy is classified into cell therapy, however, we have aimed to produce acellular PRP and study whether it is effective, differing from that PRP therapy is positioned at cell therapy.
In our studies, gelling and activated PRP cannot be flashed through the filters, at the point of gel condition. At the final stage, it is shown that five times dilution of gelled PRP can be smooth flashed.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (37 results)

All 2017 2016 2015

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Acknowledgement Compliant: 1 results,  Open Access: 2 results) Presentation (22 results) (of which Int'l Joint Research: 3 results,  Invited: 9 results) Book (5 results)

  • [Journal Article] 自己多血小板血漿(PRP)による皮膚再生2017

    • Author(s)
      楠本健司
    • Journal Title

      Derma

      Volume: 262 Pages: 1-4

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Easy-to-Use Preservation and Application of Platelet-Rich Plasma in Combination Wound Therapy With a Gelatin Sheet and Freeze-Dried Platelet-Rich Plasma: A Case Report.2016

    • Author(s)
      Morimoto N, Kakudo N, Ogura T, Hara T, Matsui M, Yamamoto M, Tabata Y, Kusumoto K.
    • Journal Title

      Eplasty

      Volume: 16

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 【PRPの適応疾患と今後の展望】 PRPの創傷手術時の創への使用2016

    • Author(s)
      三宅ヨシカズ, 福田智, 楠本健司
    • Journal Title

      形成外科

      Volume: 59 Pages: 944-949

    • Related Report
      2016 Research-status Report
  • [Journal Article] 【PRPの適応疾患と今後の展望】 PRPの滑液嚢胞への応用2016

    • Author(s)
      三宅ヨシカズ, 福田智, 楠本健司
    • Journal Title

      形成外科

      Volume: 59 Pages: 950-955

    • Related Report
      2016 Research-status Report
  • [Journal Article] 【PRPの適応疾患と今後の展望】 PRP療法の美容医療(シワ)への応用2016

    • Author(s)
      福田智, 三宅ヨシカズ, 楠本健司
    • Journal Title

      形成外科

      Volume: 59 Pages: 956-963

    • Related Report
      2016 Research-status Report
  • [Journal Article] 【PRPの適応疾患と今後の展望】 PRP療法の現況と今後の展望2016

    • Author(s)
      楠本健司
    • Journal Title

      形成外科

      Volume: 59 Pages: 974-979

    • Related Report
      2016 Research-status Report
  • [Journal Article] Platelet-rich plasma stimulates human dermal fibroblast proliferation via a Ras-dependent extracellular signal-regulated kinase 1/2 pathway.2016

    • Author(s)
      Hara T, Kakudo N, Morimoto N, Ogawa T, Lai F, Kusumoto K.
    • Journal Title

      Journal of Artificial Organs

      Volume: 19 Issue: 4 Pages: 372-377

    • DOI

      10.1007/s10047-016-0913-x

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Angiogenic effect of platelet-rich plasma combined with gelatin hydrogel granules injected into murine subcutis.2015

    • Author(s)
      Kakudo N, Morimoto N, Ogawa T, Hihara M, Notodihardjo PV, Matsui M, Tabata Y, Kusumoto K
    • Journal Title

      J Tissue Eng Regen Med.

      Volume: 10 Issue: 7 Pages: 2091-2091

    • DOI

      10.1002/term.2091

    • Related Report
      2017 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] シワ治療と肌質改善のための多血小板血漿(PRP)療法2015

    • Author(s)
      楠本健司, 福田 智, 三宅ヨシカズ
    • Journal Title

      Derma. (ISSN:13430831)

      Volume: 238 Pages: 65-70

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Exploratory clinical trial of combination wound therapy with a gelatin sheet and platelet-rich plasma in patients with chronic skin ulcers: study protocol.2015

    • Author(s)
      Morimoto N, Kakudo N, Matsui M, Ogura T, Hara T, Suzuki K, Yamamoto M, Tabata Y, Kusumoto K
    • Journal Title

      BMJ open (ISSN:20446055)

      Volume: 5 Issue: 5 Pages: 1-6

    • DOI

      10.1136/bmjopen-2015-007733

    • NAID

      120005820866

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] The effect of platelet rich plasma in proliferation of human adipose-derived stem cells2017

    • Author(s)
      来方遠, 覚道奈津子, 森本尚樹, 竹谷茂, 原朋也, 尾川武史, 楠本健司
    • Organizer
      第16回日本再生医療学会総会
    • Place of Presentation
      仙台市、仙台国際センター
    • Year and Date
      2017-03-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 自己多血小板血漿(PRP)療法による若返り2017

    • Author(s)
      楠本健司
    • Organizer
      第17回日本抗加齢医学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 自己多血小板血漿(PRP)療法による皮膚再生2017

    • Author(s)
      楠本健司
    • Organizer
      第116回日本皮膚科学総会・学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 多血小板血漿(PRP):総説2017

    • Author(s)
      楠本健司
    • Organizer
      第35回日本美容皮膚科学会総会・学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 多血小板血漿(PRP)療法について ーその原理と慢性潰瘍、シワ治療を中心にー2017

    • Author(s)
      楠本健司
    • Organizer
      第35回日本美容皮膚科学会総会・学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] PRP療法の基本原理と慢性創傷に対する治療2017

    • Author(s)
      楠本健司
    • Organizer
      第7回細胞再生医療研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Efficacy of gelatin hydrogel-impregnated human platelet lysates in wound healing2017

    • Author(s)
      Sharon Claudia Notodihardjo, Naoki Morimoto, Natsuko Kakudo, Toshihito Mitsui, Le Tien Minh, Kenji Kusumoto
    • Organizer
      The 26th Research Council Meeting of Japan Society of Plastic and Reconstructive Surgery
    • Related Report
      2017 Annual Research Report
  • [Presentation] Efficacy of the Concentrated Plate Lysate-Impregnated Gelatin Hydrogel2017

    • Author(s)
      Sharon Claudia Notodihardjo, Naoki Morimoto, Natsuko Kakudo, Toshihito Mitsui, Tien Minh Le, Kenji Kusumoto
    • Organizer
      The 9th Congress of Japanese Society for PRP Therapy
    • Related Report
      2017 Annual Research Report
  • [Presentation] Analysis of Cell Cycle and DNA Synthesis of Human Adipose Stem Cells Treated with Platelet Rich Plasma2017

    • Author(s)
      来 方えん, 覚道奈津子, 森本尚樹, 竹谷 茂, 原 朋也, 尾川武史, 楠本健司
    • Organizer
      The 9th Congress of Japanese Society for PRP Therapy
    • Related Report
      2017 Annual Research Report
  • [Presentation] Platelet-Rich Plasma and the ulcer treatment with various applications.2016

    • Author(s)
      Kenji Kusumoto, Satoshi Fukuda, Yoshikazu Miyake, Naoki Morimoto, Natsuko Kakudo, Tsunetaka Ogura, Tomoya Hara, Rina Koseki
    • Organizer
      5th congress of WUWHS2016
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2016-09-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Easy-to-use preservation and application of platelet-rich plasma; The combination wound therapy with a gelatin sheet and freeze-dried platelet-rich plasma.2016

    • Author(s)
      Naoki Morimoto, Natsuko Kakudo, Rina Koseki, Tsunetaka Ogura, Tomoya Hara, Kenji Kusumoto
    • Organizer
      5th congress of WUWHS2016
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2016-09-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] ヒト脂肪幹細胞における多血小板血漿の増殖効果2016

    • Author(s)
      来方遠, 覚道奈津子, 森本尚樹, 原朋也, 楠本健司
    • Organizer
      第25回日本形成外科学会基礎学術集会
    • Place of Presentation
      大阪市、コングレコンベンションセンター
    • Year and Date
      2016-09-15
    • Related Report
      2016 Research-status Report
  • [Presentation] 形成外科・美容外科領域における多血小板血漿(PRP)の臨床応用2016

    • Author(s)
      楠本健司
    • Organizer
      第15回日本再生医療学会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2016-03-19
    • Related Report
      2015 Research-status Report
  • [Presentation] 「形成外科における再生医療」美容医療における再生医療2016

    • Author(s)
      楠本健司
    • Organizer
      第59回日本形成外科学会総会・学術集会
    • Place of Presentation
      福岡市、福岡国際会議場
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Platelet-rich plasma and the combination usage at the adipoinjection.2016

    • Author(s)
      Kenji Kusumoto
    • Organizer
      The3rd Chinese Academic Conference on Adipose Plastic Surgery & Symposium on Adipose Transplantation
    • Place of Presentation
      Shanghai, China
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 多血小板血漿(PRP)を用いたアンチエイジング2016

    • Author(s)
      楠本健司
    • Organizer
      第10回見た目のアンチエイジング研究会
    • Place of Presentation
      東京、東京大学
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 再生医療等安全性確保法施行後の市中病院における多血小板血漿PRPを用いた治療について2016

    • Author(s)
      笹尾卓史, 福田智, 楠本健司
    • Organizer
      第114回関西形成外科学会学術集会
    • Place of Presentation
      高槻市、大阪医科大学
    • Related Report
      2016 Research-status Report
  • [Presentation] 多血小板血漿(PRP)と種々の臨床応用2016

    • Author(s)
      楠本健司
    • Organizer
      第22回千葉県形成外科研究会
    • Place of Presentation
      千葉市、京葉銀行文化プラザ
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 多血小板血漿(PRP)と育毛、その他の臨床領域での応用について2016

    • Author(s)
      楠本健司
    • Organizer
      第21回臨床毛髪学会学術集会
    • Place of Presentation
      横浜市、はまぎんホール
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 当科で試みている難治性潰瘍患者の診療・治療体系2015

    • Author(s)
      福田智, 仲野雅之, 白澤保子, 福島聡美, 楠本健司
    • Organizer
      第17回日本褥瘡学会学術集会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2015-08-28
    • Related Report
      2015 Research-status Report
  • [Presentation] 多血小板血漿(PRP)療法と再生医療等安全性確保法2015

    • Author(s)
      楠本健司
    • Organizer
      第15回日本抗加齢医学会総会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2015-05-31
    • Related Report
      2015 Research-status Report
  • [Presentation] 皮膚潰瘍に対するMagellan Autologous Platelet Separator Systemを用いた治療の経験2015

    • Author(s)
      覚道奈津子, 森本尚樹, 日原正勝, 小倉常敬, 原朋也, 鈴木健司, 楠本健司
    • Organizer
      第58回日本形成外科学会総会・学術集会
    • Place of Presentation
      ウエスティン都ホテル京都
    • Year and Date
      2015-04-10
    • Related Report
      2015 Research-status Report
  • [Book] 再生医療の応用;外科系医師が知っておくべき創傷治療のすべて2017

    • Author(s)
      楠本健司
    • Total Pages
      7
    • Publisher
      南江堂
    • Related Report
      2017 Annual Research Report
  • [Book] 多血小板血漿(PRP)療法 ;患者満足度ベストを目指す 非手術・低侵襲 美容外科 形成外科学に基づいた考え方とテクニックの実際2016

    • Author(s)
      楠本健司, 福田智, 三宅ヨシカズ
    • Total Pages
      8
    • Publisher
      南江堂
    • Related Report
      2016 Research-status Report
  • [Book] 多血小板血漿(PRP)療法2016

    • Author(s)
      楠本健司、福田智、三宅ヨシカズ
    • Total Pages
      8
    • Publisher
      南江堂
    • Related Report
      2015 Research-status Report
  • [Book] 慢性創傷治療の実際 再生医療の応用2016

    • Author(s)
      楠本健司
    • Total Pages
      5
    • Publisher
      南江堂
    • Related Report
      2015 Research-status Report
  • [Book] 創傷治療の歴史2015

    • Author(s)
      楠本健司
    • Total Pages
      3
    • Publisher
      克誠堂
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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