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Neuronal regeneration by trophic factors secreted from bone marrow stromal cells

Research Project

Project/Area Number 15K10957
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Plastic surgery
Research InstitutionAino University

Principal Investigator

Nakano Norihiko  藍野大学, 中央研究施設, 准教授 (40322721)

Co-Investigator(Kenkyū-buntansha) 井出 千束  藍野大学, 医療保健学部・中央研究施設, 教授 (70010080)
Co-Investigator(Renkei-kenkyūsha) SUZUKI Yoshihisa  公益財団法人田附興風会, 医学研究所, 研究員 (30243025)
KANEKIYO Kenji  藍野大学, 中央研究施設, 講師 (20525399)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords神経再生 / 骨髄間質細胞 / 脊髄損傷
Outline of Final Research Achievements

There is no effective treatments for spinal cord injury (SCI), although there are about 100,000 patients with SCI in our country. We have reported that transplantation of bone marrow stromal cells (BMSCs) is safe and effective against SCI in rats and humans. In this study, it was found that injection of the conditioned medium (CM) of BMSCs promotes axonal regeneration and improves locomotor behaviors in spinal cord injured rats without transplanting the BMSCs themselves. In addition, it was revealed that BMSCs secrete some neurotrophic factors to promote neuronal regeneration, and it seems that the combination of these factors secreted by BMSCs cooperate are effective for neuronal regeneration.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (25 results)

All 2018 2017 2016 2015

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (18 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results)

  • [Journal Article] Effects of intrathecal injection of the conditioned medium of bone marrow stromal cells on the spinal cord injury of rats.2018

    • Author(s)
      Kanekiyo K, Homma T, Nakano N, Yamada Y, Tamachi M, Suzuki Y, Fukushima M, Saito F, Ide C.
    • Journal Title

      Journal of Neurotrauma

      Volume: 35 Issue: 3 Pages: 521-532

    • DOI

      10.1089/neu.2017.5201

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effects of multiple-injection of bone marrow mononuclear cells on spinal cord injury of rats.2017

    • Author(s)
      Kanekiyo K, Nakano N, Homma T, Yamada Y, Tamachi M, Suzuki Y, Fukushima M, Saito F, Ide C.
    • Journal Title

      J Neurotrauma

      Volume: 1 Issue: 21 Pages: 3003-3011

    • DOI

      10.1089/neu.2016.4841

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of trophic factors on the treatment of spinal cord injury in rats.2017

    • Author(s)
      Ide Chizuka, Nakano Norihiko, Kanekiyo Kenji, Yamada Yoshihiro, Homma Tamami, Tamachi Masahiro, Abe Seiya, Miyamoto Chimi, Tsukagoshi Chihiro.
    • Journal Title

      Aino Journal

      Volume: 16

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 骨髄間質細胞由来因子による神経再生2017

    • Author(s)
      中野法彦、兼清健志、井出千束
    • Journal Title

      BIO Clinica

      Volume: 32 Pages: 82-86

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Transplantation of choroid plexus epithelial cells into contusion-injured spinal cord of rats.2016

    • Author(s)
      Kanekiyo K, Nakano N, Noda T, Yamada Y, Suzuki Y, Ohta M, Yokota A, Fukushima M, Ide C.
    • Journal Title

      Restor Neurol Neurosci

      Volume: 34 Issue: 3 Pages: 347-366

    • DOI

      10.3233/rnn-150546

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] NTAK/Neuregulin-2 secreted by astrocytes promotes survival and neurite outgrowth via ErbB3.2016

    • Author(s)
      Nakano N, Kanekiyo K, Nakagawa T, Asahi M, and Ide C.
    • Journal Title

      Neuroscience Letters.

      Volume: 622 Pages: 88-94

    • DOI

      10.1016/j.neulet.2016.04.050

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cell transplantation for the treatment of spinal cord injury - bone marrow stromal cells and choroid plexus epithelial cells.2016

    • Author(s)
      Ide C, Nakano N, Kanekiyo K.
    • Journal Title

      Neural Regen Res

      Volume: 11 Pages: 1385-88

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 脊髄損傷モデルラットに対する骨髄間質細胞培養上清の脳室内投与の効果2018

    • Author(s)
      兼清健志、中野法彦、安部征哉、塚越千尋、宮本陳敏、井出千束
    • Organizer
      第17回日本再生医療学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脊髄損傷モデルラットに対する骨髄間質細胞培養上清の効果2018

    • Author(s)
      兼清健志、中野法彦、安部征哉、塚越千尋、宮本陳敏、井出千束
    • Organizer
      第123回日本解剖学会総会・全国学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脊髄損傷モデルラットに対する骨髄由来単核細胞の複数回移植効果2017

    • Author(s)
      兼清健志、中野法彦、鈴木義久、井出千束
    • Organizer
      第122回日本解剖学会総会・全国学術集会
    • Place of Presentation
      長崎大学(長崎市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] 骨髄由来単核細胞の脊髄損傷モデルラットへの複数回移植効果の検討2017

    • Author(s)
      兼清健志、中野法彦、鈴木義久、井出千束
    • Organizer
      第16回日本再生医療学会総会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Year and Date
      2017-03-07
    • Related Report
      2016 Research-status Report
  • [Presentation] NTAK/Neuregulin-2 secreted by astrocytes promotes survival and neurite outgrowth of neurons via ErbB32017

    • Author(s)
      Nakano N, Kanekiyo K, Nakagawa T, Asahi M, and Ide C
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Effects of multiple-injection of bone marrow-derived mononuclear cells on spinal cord injury of rats.2017

    • Author(s)
      Kanekiyo K, Nakano N, Suzuki Y, and Ide C
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Therapeutic potential of choroid plexus epithelial cells for spinal cord injury.2017

    • Author(s)
      Kanekiyo K, Nakano N, and Ide C.
    • Organizer
      International Symposium, Systems Glycobiology and Beyond, ―Toward a bridge between fundamental research and applied science―
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Therapeutic effect of multiple-injection of bone marrow-derived mononuclear cells on rat spinal cord injury2017

    • Author(s)
      Kanekiyo K, Nakano N, Suzuki Y, and Ide C
    • Organizer
      Consortium of Biological Sciences 2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] アストロサイト由来のNTAK/Neuregulin-2のニューロンに対する作用2016

    • Author(s)
      中野法彦、兼清健志、中川孝俊、朝日通雄、井出千束
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター/東北大学(仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Research-status Report
  • [Presentation] 脈絡叢上皮細胞移植によるラット脊髄損傷修復効果2016

    • Author(s)
      兼清健志、中野法彦、本間玲実、野田亨、井出千束
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター/東北大学(仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Research-status Report
  • [Presentation] Transplantation of choroid plexus epithelial cells promotes axon regeneration in spinal cord injury.2016

    • Author(s)
      兼清健志、中野法彦、本間玲実、野田亨、井出千束
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Presentation] Transplantation of choroid plexus epithelial cells into contusion-injured spinal cord of rats.2016

    • Author(s)
      兼清健志、中野法彦、本間玲実、野田亨、井出千束
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      パレットふくしま(福島県・郡山市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] 脊髄損傷モデルラットにおける脈絡叢上皮細胞移植による神経再生効果2016

    • Author(s)
      兼清健志、中野法彦、本間玲実、野田亨、井出千束
    • Organizer
      第15回日本再生医療学会総会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2016-03-17
    • Related Report
      2015 Research-status Report
  • [Presentation] Cell Transplantation for the treatment of spinal cord injury-bone marrow stromal cells and choroid plexus epithelial cells2016

    • Author(s)
      Ide C, Kanekiyo K,Nakano N.
    • Organizer
      2016 International Neural Regeneration Symposium (INRS 2016) & Pacific Symposium on Neural regeneration (APSNR 2016)
    • Place of Presentation
      Yinchuan (China)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Cell transplantation for the treatment of spinal cord injury2016

    • Author(s)
      Kanekiyo K,Nakano N, Ide C.
    • Organizer
      2016 International Neural Regeneration Symposium (INRS 2016) & Pacific Symposium on Neural regeneration (APSNR 2016)
    • Place of Presentation
      Yinchuan (China)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 脊髄損傷ラットに対する脈絡叢上皮細胞移植効果2015

    • Author(s)
      兼清健志、中野法彦、本間玲実、野田亨、井出千束
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会大会合同大会(BMB2015)
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] 脊髄損傷ラットへの脈絡叢上皮細胞移植効果2015

    • Author(s)
      兼清健志、中野法彦、本間玲実、野田亨、井出千束
    • Organizer
      第36回日本組織細胞化学会総会・学術集会
    • Place of Presentation
      関西医科大学(大阪府・枚方市)
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
  • [Presentation] Therapeutic effect of choroid plexus epithelial cell transplantation on spinal cord injury.2015

    • Author(s)
      兼清健志、中野法彦、本間玲実、野田亨、井出千束
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター(神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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