| Project/Area Number |
15K10958
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
垣淵 正男 兵庫医科大学, 医学部, 教授 (50252664)
西本 聡 兵庫医科大学, 医学部, 教授 (30281124)
河合 建一郎 兵庫医科大学, 医学部, 准教授 (80423177)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 高齢 / 皮膚創傷治癒 / 活性酸素 / 活性酸素不活化酵素 / 線維芽細胞 / Superoxide Dismutase / 創傷治癒 / 皮膚線維芽細胞 / 伸展刺激 |
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| Outline of Final Research Achievements |
To investigate a role of reactive oxygen species (ROS) and antioxidant on wound healing with aging, young and aged mice were utilized for the assessment. The results of in vitro and in vivo experiments suggested that ROS during inflammatory phase of wound healing process induced wound contraction via differentiation of dermal fibroblasts into myofibroblasts, leading to promotion of wound healing. Appropriate amount of ROS can promote wound healing. But, excessive amount of ROS can cause cell dysfunction and apoptosis, resulting in impairment of wound healing. The expression of antioxidant in aged mice and the dermal fibroblasts was decreased with aging. Therefore, the intolerance against ROS in aged mice may contribute to impairment of wound healing in aged mice.
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