Does the MUSE cell transplantation promote skin wound healing and reconstruct skin structure?
| Project/Area Number |
15K10962
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | 独立行政法人国立病院機構(東京医療センター臨床研究センター) |
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Principal Investigator |
Ochiai Hiroko 独立行政法人国立病院機構(東京医療センター臨床研究センター), その他部局等, 室長 (60374162)
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| Project Period (FY) |
2015-10-21 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 間葉系幹細胞 / 創傷治癒 / 皮膚潰瘍 / MUSE細胞 / 皮膚創傷治癒 / 皮膚再生 |
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| Outline of Final Research Achievements |
The wound healing was promoted when the MUSE (Multi-lineage differentiating stress enduring) cells were transplanted into the skin ulcer of rat. And the degree of wound healing was almost equal to the case of the BMSC (Bone marrow stromal cell) transplantation. In addition, the MUSE cells and the BMSCs couldn't be recognized in the tissues of the wound 14days after cell transplantation. There was the possibility that a paracrine effect primarily promoted the healing of cutaneous wounds.
By culturing the MUSE cells of rat, lesser cell proliferation was recognized when they were cultured in culture fluid with autologous serum than with FBS.
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Report
(4 results)
Research Products
(10 results)
