| Project/Area Number |
15K10963
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Jichi Medical University (2016-2017)
Shizuoka Cancer Center Research Institute (2015) |
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Principal Investigator |
Inoue Keita 自治医科大学, 医学部, 非常勤講師 (80618520)
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| Co-Investigator(Kenkyū-buntansha) |
中川 雅裕 静岡県立静岡がんセンター(研究所), その他部局等, 研究員 (00285793)
三枝 紀子 (財)冲中記念成人病研究所, その他部局等, 研究員 (10642639)
秋山 靖人 静岡県立静岡がんセンター(研究所), その他部局等, 研究員 (70222552)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 免疫療法 / 樹状細胞 / 皮弁 / リンパ管 / 腫瘍免疫 / リンパ管静脈吻合 / 免疫皮弁 / ブタ / リンパ節 / 悪性腫瘍 |
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| Outline of Final Research Achievements |
The conceptual "immunologically augumented skin flap (immuno-flap)" is a novel anti-cancer approach, in which ant-cancer immunity is evoked by injection of dendritic cells stimulated by tumor specific antigens. The immuno-flap has been proved to be affective in a rat model so far. In this project,2015-2017,rat and porcine models were utilized to analyze to the traffics of GFP labeled cells and anatmy of lymphatic channels, suggesting porcine model was useful to examine the anti-cancer effect by immuno-flap.
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