| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The aims of this study were to clarify mechanisms of delayed neurologic sequelae (DNS) after carbon monoxide (CO) poisoning and to establish methods for early diagnosis and outcome prediction of DNS.
One hundred patients with acute CO poisoning were enrolled in this study. Based on the analyses of the clinical, laboratory, and radiological data, poor outcomes of DNS were associated with advanced age and earlier onset. Myelin basic protein (MBP) level in the cerebrospinal fluid (CSF) can serve as a sensitive predictor of both the development and outcomes of DNS.
In proton magnetic resonance spectroscopy (MRS) study, NAA/Cr ratios were lower in patients with DNS than in those without DNS within 1 week after CO exposure. Cho/Cr ratios were higher, and NAA/Cr and NAA/Cho ratios lower in patients with DNS at 1 month. Proton MRS within 1 week may be useful for predicting DNS development. Proton MRS at 1 month may be useful for discriminating patients with DNS and predicting long-term outcomes.
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