Prospective randomized trial fibrinogen concentrates for hemorrhagic shock patients.
| Project/Area Number |
15K10969
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Murata Kiyoshi 東京医科歯科大学, 医学部附属病院, 非常勤講師 (60527175)
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| Co-Investigator(Kenkyū-buntansha) |
大友 康裕 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (40176946)
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| Project Period (FY) |
2015-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 外傷外科 / 出血性ショック / 大量輸血 / フィブリノゲン / 外傷性血液凝固障害 |
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| Outline of Final Research Achievements |
We cannot use fibrinogen concentrates to massive bleeding patients in Japan. The aim of this study is to clear the effectiveness of fibrinogen concentrates for hemorrhagic shock patients. Firstly, We performed big data analysis using DPC data. Secondly, we conduct randomized trial. This two studies suggest no benefit of fibrinogen concentrates for hemorrhagic shock patients to improve mortality and to decrease amount of transfusion.
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| Academic Significance and Societal Importance of the Research Achievements |
残念ながら本研究では出血性ショック患者に対するフィブリノゲン濃縮製剤の効果を証明できなかった。しかしながら保険適応外でも利用されている現状はDPCデータでも確認でき、その効果が限定的である可能性が示された。さらなる研究が必要ではあるが、フィブリノゲン濃縮製剤の役割が今後明確になっていく中で、貴重なフィブリノゲン濃縮製剤の適正利用が進むものと考えられ、今後の医療現場での大量出血患者に対する適切な治療選択に向けて一定の情報として発信できる結果が得られた。
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Report
(7 results)
Research Products
(35 results)
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[Journal Article] Development of Novel Criteria of the "Lethal Triad" as an Indicator of Decision Making in Current Trauma Care: A Retrospective Multicenter Observational Study in Japan.2016
Author(s)
Endo A, Shiraishi A, Otomo Y, Kushimoto S, Saitoh D, Hayakawa M, Ogura H, Murata K, Hagiwara A, Sasaki J, Matsuoka T, Uejima T, Morimura N, Ishikura H, Takeda M, Kaneko N, Kato H, Kudo D, Kanemura T, Shibusawa T, Hagiwara Y, Furugori S, Nakamura Y, Maekawa K, Mayama G, Yaguchi A, Kim S, Takasu O, Nishiyama K.
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Journal Title
Critical Care Medicine
Volume: 4
Issue: 9
Pages: 797-803
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] HIGH D-DIMER LEVELS PREDICT A POOR OUTCOME IN PATIENTS WITH SEVERE TRAUMA, EVEN WITH HIGH FIBRINOGEN LEVELS ON ARRIVAL: A MULTICENTER RETROSPECTIVE STUDY.2016
Author(s)
Hayakawa M, Maekawa K, Kushimoto S, Kato H, Sasaki J, Ogura H, Matauoka T, Uejima T, Morimura N, Ishikura H, Hagiwara A, Takeda M, Kaneko N, Saitoh D, Kudo D, Kanemura T, Shibusawa T, Furugori S, Nakamura Y, Shiraishi A, Murata K, Mayama G, Yaguchi A, Kim S, Takasu O, Nishiyama K.
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Journal Title
SHOCK
Volume: 45
Issue: 3
Pages: 308-314
DOI
NAID
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] 新しい外傷死の三徴2016
Author(s)
村田希吉
Organizer
第44回日本救急医学会総会
Place of Presentation
新高輪プリンスホテル（東京）
Year and Date
2016-11-17
Related Report
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