A novel strategy of acute lung injury: Targeting sphingolipid signaling
| Project/Area Number |
15K10970
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Kawasaki Medical School (2016-2017)
Kanazawa University (2015) |
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Principal Investigator |
Okamoto Yasuo 川崎医科大学, 医学部, 教授 (80293877)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | スフィンゴシン1-リン酸 / 急性肺損傷 / 血管バリア機能 / リポポリサッカライド |
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| Outline of Final Research Achievements |
Sphingosine 1-phosphate (S1P) is a lysophospholipid mediator and plays an important role in the regulation of vascular barrier function. In this study, we found that S1P2 mediates the protection from acute lung injury possibly through inhibiting endothelial nitric oxide synthase, pointing to S1P2 as a promising novel target for treating acute lung injury.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Sphingosine-1-phosphate receptor-2 facilitates pulmonary fibrosis through potentiating IL-13 pathway in macrophages.2018
Author(s)
1.Zhao J, Okamoto Y, Asano Y, Ishimaru K, Aki S, Yoshioka K, Takuwa N, Wada T, Inagaki Y, Takahashi C, Nishiuchi T, Takuwa Y
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Journal Title
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Augmented sphingosine 1 phosphate receptor-1 signaling in cardiac fibroblasts induces cardiac hypertrophy and fibrosis through angiotensin II and interleukin-6.2017
Author(s)
Ohkura SI, Usui S, Takashima SI, Takuwa N, Yoshioka K, Okamoto Y, Inagaki Y, Sugimoto N, Kitano T, Takamura M, Wada T, Kaneko S, Takuwa Y.
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Journal Title
PLoS One.
Volume: 12
Issue: 8
Pages: e0182329-e0182329
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 脂質メディエーターであるN-アシルエタノールアミンとリゾホスファチジン酸の新規生合成機構2017
Author(s)
坪井一人, Rahman Iffat Ara Sonia, Hussain Zahir, 山下量平, 岡本蓉子, 宇山徹, 竹之内康広, 田中保, 岡本安雄, 徳村彰, 上田夏生
Organizer
第28回創薬・薬理フォーラム岡山
Related Report
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[Presentation] Deletion of sphingosine 1-phospahte (S1P) receptor-2 (S1P2) inhibits lung fibrosis through altering alveolar macrophage polarization and senescence in mice2015
Author(s)
Juanjuan Zhao, Yasuo Okamoto, Kazuaki Yoshioka, Sho Aki, Pham Quynh Hoa, Azadul MD Kabir Sarker, Khin Thuzar Aung, Noriko Takuwa, Yutaka Inagaki, Chiaki Takahashi, Takashi Wada, Yoh Takuwa
Organizer
第38回日本分子生物学会・第88回日本生化学会
Place of Presentation
兵庫県神戸市
Year and Date
2015-12-01
Related Report
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[Presentation] Role of S1P2 in inflammation and fibrosis2015
Author(s)
Yoh Takuwa, Juanjuan Zhao, Yasuo Okamoto, Kazuaki Yoshioka, Noriko Takuwa
Organizer
14 th International Conference on Bioactive Lipids in Cancer, Inflammation, and Related Diseases Plenary Lecture
Place of Presentation
ハンガリー ブタペスト
Year and Date
2015-07-12
Related Report
Invited
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