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The possibility of therapeutic application of temporary total liquid ventilation in rat acute respiratory distress syndrome model.

Research Project

Project/Area Number 15K10972
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Emergency medicine
Research InstitutionUniversity of Yamanashi

Principal Investigator

HARII Norikazu  山梨大学, 大学院総合研究部, 准教授 (80377522)

Co-Investigator(Kenkyū-buntansha) 武岡 真司  早稲田大学, 理工学術院, 教授 (20222094)
松田 兼一  山梨大学, 大学院総合研究部, 教授 (60282480)
森口 武史  山梨大学, 大学院総合研究部, 講師 (60422680)
後藤 順子  山梨大学, 大学院総合研究部, 医学研究員 (60530102)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords完全液体呼吸 / 急性呼吸窮迫症候群 / ARDS / total liquid ventilation
Outline of Final Research Achievements

Mechanical ventilation in acute respiratory distress syndrome is simply used to assist or replace spontaneous breathing and does not directly improve lung damage. We previously reported that the oxygen micro/nano-bubbles containing a sufficient amount of oxygen are useful in producing oxygen-rich liquid suitable for liquid ventilation, and a total liquid ventilation system was established using saline-based oxygen micro/nano-bubble dispersions in rats. In this study, we investigated whether lung damage can be improved by removing pathogens by temporary total liquid ventilation in rat acute respiratory distress syndrome model. We conducted experiments about 1) optimization of liquid ventilation condition, 2) evaluation of returning to general gas ventilation from liquid ventilation, 3) preparation of ARDS model rats.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2017

All Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] 酸素マイクロ・ナノバブル分散液を用いた完全液体換気から気体換気への復帰2017

    • Author(s)
      佐藤 啓斗, 針井 則一, 宮坂 武寛, 松田 兼一, 武岡 真司
    • Organizer
      第24回日本血液代替物学会(東京)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Application of micro/nano bubble dispersion for total liquid ventilation2017

    • Author(s)
      Hiroto Sato, Takehiro Miyasaka, Norikazu Harii, Kenichi Matsuda, Shinji Takeoka
    • Organizer
      44th Annual Congress of the European Society for Artificial Organs (Sep. 2017, VIENNA, Austria)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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