The possibility of therapeutic application of temporary total liquid ventilation in rat acute respiratory distress syndrome model.

• Project/Area Number: 15K10972
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: University of Yamanashi
• Principal Investigator: HARII Norikazu 山梨大学, 大学院総合研究部, 准教授 (80377522)
• Co-Investigator(Kenkyū-buntansha): 武岡 真司 早稲田大学, 理工学術院, 教授 (20222094) ; 松田 兼一 山梨大学, 大学院総合研究部, 教授 (60282480) ; 森口 武史 山梨大学, 大学院総合研究部, 講師 (60422680) ; 後藤 順子 山梨大学, 大学院総合研究部, 医学研究員 (60530102)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 完全液体呼吸 / 急性呼吸窮迫症候群 / ARDS / total liquid ventilation

Outline of Final Research Achievements

Mechanical ventilation in acute respiratory distress syndrome is simply used to assist or replace spontaneous breathing and does not directly improve lung damage. We previously reported that the oxygen micro/nano-bubbles containing a sufficient amount of oxygen are useful in producing oxygen-rich liquid suitable for liquid ventilation, and a total liquid ventilation system was established using saline-based oxygen micro/nano-bubble dispersions in rats. In this study, we investigated whether lung damage can be improved by removing pathogens by temporary total liquid ventilation in rat acute respiratory distress syndrome model. We conducted experiments about 1) optimization of liquid ventilation condition, 2) evaluation of returning to general gas ventilation from liquid ventilation, 3) preparation of ARDS model rats.

Research Products

• [Presentation] 酸素マイクロ・ナノバブル分散液を用いた完全液体換気から気体換気への復帰 (2017)
  • Author(s): 佐藤 啓斗, 針井 則一, 宮坂 武寛, 松田 兼一, 武岡 真司
  • Organizer: 第24回日本血液代替物学会（東京）
• [Presentation] Application of micro/nano bubble dispersion for total liquid ventilation (2017)
  • Author(s): Hiroto Sato, Takehiro Miyasaka, Norikazu Harii, Kenichi Matsuda, Shinji Takeoka
  • Organizer: 44th Annual Congress of the European Society for Artificial Organs (Sep. 2017, VIENNA, Austria)
  • Int'l Joint Research