Intracranial aneurysm rupture prevention by modulating gut microbiota
| Project/Area Number |
15K10974
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
Makino Hiroshi 浜松医科大学, 医学部附属病院, 講師 (10397408)
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| Research Collaborator |
HASHIMOTO Tomoki Barrow Neurology Institute, Research Director
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 脳動脈瘤 / くも膜下出血 / 腸内細菌 / マウスモデル / 脳動脈瘤破裂 / 動物モデル / 乳酸菌 |
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| Outline of Final Research Achievements |
Intracranial aneurysm rupture causes poor outcome. For the rupture prevention, open surgery and intra-vascular coiling has been performed. However, more noninvasive methods such as pharmacological prevention has been required.
One of the main targets of the rupture prevention is inflammation. Recent study reports that gut microbiota changes red meat ingredients into inflammation inducing substance. The substance causes arterial inflammation. Also, lactic acid bacteria have anti-inflammatory action. In this study, we tried intracranial aneurysm rupture prevention by modulating gut microbiota with lactic acid bacteria and antibiotics. We could not finish the research within the study period. We are continuing the research.
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Report
(3 results)
Research Products
(9 results)
