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Establishment of methods for immune response analysis of lymphocytes and neutrophils against sepsis and trauma

Research Project

Project/Area Number 15K10979
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Emergency medicine
Research InstitutionOsaka University

Principal Investigator

Shimizu Kentaro  大阪大学, 医学部附属病院, 助教 (60379203)

Co-Investigator(Kenkyū-buntansha) 高橋 弘毅  関西医科大学, 医学部, 助教 (30609590)
吉矢 和久  大阪大学, 医学部附属病院, 助教 (40379201)
嶋津 岳士  大阪大学, 医学系研究科, 教授 (50196474)
池田 光憲  大阪大学, 医学部附属病院, 医員 (60548444)
小倉 裕司  大阪大学, 医学系研究科, 准教授 (70301265)
松本 寿健  大阪大学, 医学系研究科, 招へい教員 (70644003)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords免疫 / インフラマソーム / T細胞 / 痰 / 保存 / フローサイトメトリー / 全身性炎症反応 / 吸引痰 / 免疫担当細胞 / CD4+T細胞 / 好中球 / リンパ球 / 免疫細胞 / B細胞 / セプシス / 外傷 / 制御性T細胞
Outline of Final Research Achievements

Immune system occurred inflammatory response against host in respond to not only pathogenic organisms but also self tissues following trauma. Evaluation and modulation of this inflammatory response is critical for treatments of critically illnesses. In this research, we investigated following results; 1. A preservation method of immune cells was developed. 2. Inflammasome, which is one of the danger signals, was activated following injury. CD8+Tcells were decreased and CD4+Tcells and Bcells were increased. 3. Immune cells from aspirated sputum mainly consisted of neutrophils. There were few lymphocytes. 4. Immune response in the intestine might be different with gut microbiota.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2017 2016

All Presentation (2 results)

  • [Presentation] 重症患者の腸内細菌叢とシンバイオティクス療法2017

    • Author(s)
      清水 健太郎
    • Organizer
      第45回日本救急医学会総会・学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] サイトカインプロファイルによる敗血症患者の予後の評価2016

    • Author(s)
      松本 寿健, 清水 健太郎, 池田 光憲, 廣瀬 智也, Kang Suijin, 小倉 裕司, 田中 敏郎, 嶋津 岳士
    • Organizer
      第44回日本救急医学会
    • Place of Presentation
      グランドプリンスホテル高輪
    • Year and Date
      2016-11-17
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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