Beneficial effects of Molecular hydrogen in rat model of heat stroke

• Project/Area Number: 15K10983
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Yamaguchi University
• Principal Investigator: ODA Yasutaka 山口大学, 大学院医学系研究科, 准教授 (40397998)
• Co-Investigator(Kenkyū-buntansha): 宮内 崇 山口大学, 医学部附属病院, 助教 (40380000) ; 藤田 基 山口大学, 大学院医学系研究科, 助教 (50380001)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 熱中症 / 分子状水素 / 酸化ストレス / 全身炎症反応 / 水素水 / 炎症 / バイオマーカー

Outline of Final Research Achievements

Molecular hydrogen exerts beneficial effects of the anti-oxidative stress, anti-inflammatory, and anti-apoptotic effects in various diseases. The purpose is to investigate whether molecular hydrogen suppress oxidative stress and systemic inflammation caused by heat stroke, and exert protective effects of liver using rat model of heat stroke. H2 gas inhalation and intravenous administration of H2 ringer solution suppressed oxidative stress and systemic inflammation caused by heat stroke, and exerted protective effect of liver. In addition, molecular hydrogen increases 24-hour survival rate. Molecular hydrogen may be an effective treatment for heat stroke and clinical research will be desired.

Research Products

• [Presentation] ラット熱中症モデルを用いた分子状水素の効果の検討 (2017)
  • Author(s): 小田 泰崇、藤田 基、鶴田 良介、前川 剛志、西嶋 陽、中島 健太郎、井上 吾一、小池 国彦
  • Organizer: 第7回日本分子状水素医学生物学会