| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
Sepsis is a condition that exhibits organ dysfunction due to poor control of host biological response to infection. In recent years, multidisciplinary treatment based on effective guidelines has been applied, short-term treatment outcomes are improving, but as a result of prolonged systemic dysfunction, long-term prognosis remains poor. In this experiment, we investigated the suppression effect of the recombinant thrombomodulin (rTM), which has a strong anti-inflammatory effect, for the prolonged vascular dysfunction in sepsis, the suppression of vascular endothelial dysfunction, and the effect on the recovery phase. When rTM was added, there was a tendency to suppress the prolongation of vasoconstriction degradation caused by lipopolysaccharide (LPS). Although LPS strongly injured vascular endothelial cells, rTM showed a tendency to maintain the tissue structure without association in the occurrence of apoptosis.
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