| Project/Area Number |
15K10986
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
升田 好樹 札幌医科大学, 医学部, 教授 (10244328)
高橋 科那子 札幌医科大学, 医学部, 助教 (60772316)
赤塚 正幸 札幌医科大学, 医学部, 助教 (60808161)
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| Project Period (FY) |
2015-10-21 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 六君子湯 / グレリン / 重症患者 / 消化管蠕動 |
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| Outline of Final Research Achievements |
On the reduction of gastrointestinal peristalsis after invasion, we studied for the purpose of elucidating the mechanism of the effectiveness of rikkunshito. Peritonitis model was prepared and plasma ghrelin concentration involved in gastric peristalsis was measured. We also examined the mechanism of the effectiveness of rikkunshito against the decrease in gastric peristalsis from the viewpoint of the influence on ghrelin concentration. Dietary intake and water intake decreased after invasion recovered early by rikkunshito administration. It was suggested that the recovery of body weight was several days earlier than that of the control group in the group treated with rikkunshito. In the treated group, the concentration of activated ghrelin was high and the inactivated ghrelin concentration tended to be low, suggesting that a shift to activated ghrelin was involved in recovery of oral intake, and rikkunshito was thought to be involved in the increase of activated ghrelin.
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