A clarify of a role of remote organ failure after tissue injury

• Project/Area Number: 15K10996
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Nippon Medical School
• Principal Investigator: Tsukamoto Takeshi 日本医科大学, 医学部, 助教 (20626270)
• Co-Investigator(Kenkyū-buntansha): 増野 智彦 日本医科大学, 医学部, 講師 (00318528) ; 松居 亮平 日本医科大学, 医学部, 助教 (50727865) ; 横田 裕行 日本医科大学, 医学部, 助教授 (60182698)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 骨軟部組織損傷 / 外傷後臓器障害 / 骨軟部組織損傷モデル / 出血性ショック / HMGB-1 / Two-hit theory

Outline of Final Research Achievements

We investigated the mechanism of inflammatory response after trauma using ''Two-hit model".
Two-hit model consists of tissue-bone matrix (TBX) model and hemorrhagic shock model. TBX model is a novel model, we developed before.
TBX induced a systematic inflammatory response and attenuated a intestinal motility at 21 hours after transplantation of TBX. However "Tow-hit model" did not induced inflammatory response in our experiment.