| Project/Area Number |
15K10997
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Emergency medicine
|
|---|
| Research Institution | Aichi Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
宮部 浩道 藤田保健衛生大学, 医学部, 講師 (90398363)
野口 宏 愛知医科大学, 医学部, 教授 (20065569)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | MPO-DNA / 敗血症性ショック / 血管内皮細胞 / 血管透過性亢進 / angiopoietin 1 / tight junction / angiopoetin / neuregulin |
|---|
| Outline of Final Research Achievements |
Aim: The objectives of this study were to investigate the correlations between plasma myeloperoxidase (MPO) conjugated-DNA level with degree of organ dysfunction, disease severity, and ICU mortality in septic shock patients. Results: On day 1, septic shock patients displayed a marked increase of plasma MPO-DNA level compared with the healthy volunteers. Plasma MPO-DNA levels were significantly decreased on days 3 and 7. The MPO-DNA level on 7th day was inversely correlated with both the mean arterial pressure and P/F ratio at 7th day. Negative correlation was observed between plasma MPO-DNA level on 1st day. Positive correlation was observed between plasma MPO-DNA level on 7th day and SOFA at 7th day . Using Wilcoxon signed-rank test the high MPO-DNA on 3rd day was found to be associated with the hospital mortality
Discussion: High MPO-DNA levels at 3rd and 7th days of septic shock patients are associated with the degree of organ dysfunction and hospital mortality.
|
