Stem cell transplantation for vascular permeability and angiogenesis under surgical stress
Project/Area Number |
15K10997
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Emergency medicine
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Research Institution | Aichi Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
宮部 浩道 藤田保健衛生大学, 医学部, 講師 (90398363)
野口 宏 愛知医科大学, 医学部, 教授 (20065569)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | MPO-DNA / 敗血症性ショック / 血管内皮細胞 / 血管透過性亢進 / angiopoietin 1 / tight junction / angiopoetin / neuregulin |
Outline of Final Research Achievements |
Aim: The objectives of this study were to investigate the correlations between plasma myeloperoxidase (MPO) conjugated-DNA level with degree of organ dysfunction, disease severity, and ICU mortality in septic shock patients. Results: On day 1, septic shock patients displayed a marked increase of plasma MPO-DNA level compared with the healthy volunteers. Plasma MPO-DNA levels were significantly decreased on days 3 and 7. The MPO-DNA level on 7th day was inversely correlated with both the mean arterial pressure and P/F ratio at 7th day. Negative correlation was observed between plasma MPO-DNA level on 1st day. Positive correlation was observed between plasma MPO-DNA level on 7th day and SOFA at 7th day . Using Wilcoxon signed-rank test the high MPO-DNA on 3rd day was found to be associated with the hospital mortality Discussion: High MPO-DNA levels at 3rd and 7th days of septic shock patients are associated with the degree of organ dysfunction and hospital mortality.
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Report
(4 results)
Research Products
(8 results)
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[Presentation] Neutrophil extracellular traps induce organ damage during sepsis: protective effect of hemoperfusion with a polymyxin B cartridge.2016
Author(s)
Muhammad Aminul Huq, Yuka Kajita, Yuki Maruchi, Kato, Atsutoshi Tomino, Ruri Aoki, Hisatake Mori, Masamitsu Hashiba, Tsuguaki Terajima, Masanobu Tsuda, Kano Hideki, and Naoshi Takeyama.
Organizer
8th International Shock Congress
Place of Presentation
Tokyo
Year and Date
2016-10-03
Related Report
Int'l Joint Research
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[Presentation] INCREASED PD-1 EXPRESSION AND ALTERED T CELL REPERTOIRE DIVERSITY IN SEPTIC SHOCK PATIENTS.2015
Author(s)
Takeyama N, Tomino A, Hashiba M, Ando M, Gocho T, Miyabe H, Kano H, Tsuda M, Hattori T, Hirakawa A
Organizer
38th Annual conference on Shock
Place of Presentation
Denver, USA
Year and Date
2015-06-06
Related Report
Int'l Joint Research / Invited
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[Presentation] Plasma myeloperoxidase- and neutrophil elastase-DNA assay for measuremet of neutrophil extracellular traps2015
Author(s)
MA Huq, Tomino A, Hashiba M, Ando M, Gocho T, Miyabe H, Kano H, Tsuda M, Hattori T, Hirakawa A, Takeyama N
Organizer
38th Annual conference on Shock
Place of Presentation
Denver, USA
Year and Date
2015-06-06
Related Report
Int'l Joint Research