| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Endothelial hyper permeability is attracted attention as one of the mechanisms of the organ failure in critically ill patients. The purpose of this study was to clarify the potential of platelets or erythrocytes as modulator of the endothelial hyperpermeability.
On the cecal ligation and puncture (CLP) model of mice, there was a positive correlation between the sVE-Cadherin and the extracellular water ratio (ECW% ratio) measured by bioimpedance analysis. The characteristic changes of platelets were prominent than that of erythrocytes in early phase of sepsis. Angiopoietin-1, which acts as a positive regulating factor for VE-cadherin, decreased depending the number of platelets. Administration of the platelet rich plasma (PRP) extraction containing abundant Ang-1 suppressed increase in the ECW% on CLP mice. These findings suggested that a therapeutic potential of PRP extraction for endothelial hyperpermeability.
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