| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Recently number of patients with taste disorder increases gradually. It is known that zinc deficiency causes taste disorder. In the present study, the effect of zinc on the maintenance of sensory perception in oral regions was examined using experimental animals with dietary-induced zinc deficiency. When animals were fed with low zinc diet, increase in body weight was suppressed, and zinc contents in serum were decreased. These experimental animals showed behavioral abnormality against bitter stimulation. Immunohistochemisty of c-fos indicated the decreased number of neurons in parabranchial nucleus, one of the relay nuclei in gustatory system, response to bitter stimulation. These changes were more apparent in young animals.
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