| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
We studied about the relationship of estrogen response genes and mechanism of osteoclasts and bone metabolism using medullary bone formation model of male quail.During bone marrow culture for osteoclatogenesis, 17beta-estradiol (17b-E) added into media and induced the change of expression of some genes and proteins. Some candidate genes from the results of DNA microarray were recognized the expression change during osteoclastogenesis. Then, culture model of mice osteoclasts was established at our lab.
There are suggested that estrogen response genes of medullary bone will be helpful to find new estrogen response genes in mammalian osteoclasts and bone metabolism.
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