Examination of the physiological role of Runx2 in the regulation of phosphorus levels through the regulation of Galnt3 expression
| Project/Area Number |
15K11016
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
ROKUTANDA Satoshi 長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (60549608)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | Runx2 / Galnt3 / phosphorus / FGF23 / 高リン血症 |
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| Outline of Final Research Achievements |
The serum levels of phosphorus are regulated by FGF23. FGF23, which is mainly produced in bone, inhibits reabsorption of phosphorus in kidney, and inhibits absorption of calcium and phosphorus in intestine by inhibiting the production of active vitamin D. Galnt3（UDP-N-acetyl-D-galactosamine:polypeptide N-acetyl-D-galactosaminyltransferase 3）inhibits the processing of FGF23 by mucin type O-glycosylation of FGF23, and maintains the activity of FGF23. Runx2 induced Galnt3 expression in osteoblasts and chondrocytes. Runx2 was involved partly in the regulation of the serum levels of phosphorus through the regulation of Galnt3 expression.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Cbfb regulates bone development by stabilizing Runx family proteins.2015
Author(s)
Qin X, Jiang Q, Matsuo Y, Kawane T, Komori H, Moriishi T, Taniuchi I, Ito K, Kawai Y, Rokutanda S, Izumi S, Komori T.
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Journal Title
Journal of Bone and Mineral Research
Volume: 30
Pages: 706-14
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Cbfb plays important roles in bone development through the stabilization of Run family proteins.2015
Author(s)
2.Qin X,Jiang Q,Matsuo Y,Kawane T,Komori H,Moriishi T,Taniuchi I, Ito K,Kawai Y,Rokutanda S,Izumi S, Komori T
Organizer
The RUNX Transcription Factors in Development and Disease
Place of Presentation
Weizmann Institute of Science, Israel
Year and Date
2015-10-18
Related Report
Int'l Joint Research
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