| Project/Area Number |
15K11031
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
久保 勝俊 愛知学院大学, 歯学部, 准教授 (60329604)
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| Co-Investigator(Renkei-kenkyūsha) |
SUGITA Yoshihiko 愛知学院大学, 歯学部, 准教授 (20367618)
SATO Emiko 愛知学院大学, 歯学部, 講師 (60111001)
YOSHIDA Waka 愛知学院大学, 歯学部, 講師 (10513210)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | DNAワクチン / パピローマウイルス / ナノスフェアー / CPHナノ粒子 / テープストリッピング法 / ドラッグデリバリー / 口腔 / 癌抑制効果 / ナノ粒子 / 癌化抑制効果 / 扁平上皮癌 / naked pDNA |
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| Outline of Final Research Achievements |
The delivery system of DNA vaccine-embedded hydrophobic pullulan nanoparticles (CPH nanoparticles) with tape stripping method using oral mucosa for cancer prevention, that associated papillomavirus infection, was studied.
As a result, it was suggested that DNA vaccine-embedded CPH nanoparticles with tape stripping method was useful for cancer prevention. Therefore, it contributes to the papillomavirus-induced oral cancer prevention.
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