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Elucidation of neuro transmitters between taste cell and taste nerves

Research Project

Project/Area Number 15K11043
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Functional basic dentistry
Research InstitutionKyushu University

Principal Investigator

Yasumatsu Keiko  九州大学, 五感応用デバイス研究開発センター, 特任准教授 (50380704)

Research Collaborator Ninomiya Yuzo  
Yoshida Ryusuke  
Jiang Peihua  
Takai Shingo  
Shin Misa  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords味覚 / 鼓索神経 / うま味 / 塩味 / 酸味 / 苦味 / 脂肪味 / 伝達物質 / 味細胞 / 脂肪酸の味
Outline of Final Research Achievements

The purpose of this research is to clarify neurotransmitters between taste cells and taste nerves for salty taste, umami and fatty acids using neurophysiological methods. After determination of the best stimulus among basic taste solutions, single fiber responses were recorded while neurotransmitter reagents were intravenously administered from a cannula placed in the femoral vein.
The results were shown that umami taste via T1Rs transmitted by GLP-1 like sweet taste,and that serotonin is a transmitter for sour taste. We also reported CCK as a transmitter for bitter taste. In addition, analysis of taste nerves responding to fatty acids progressed in the present research period and, it was suggested that there is a possibility that GLP-1 may be a transmitter for fat taste.

Academic Significance and Societal Importance of the Research Achievements

脂肪酸の味、うま味は甘味と共に体に必要なカロリーをもたらすシグナルであるとともにその摂りすぎによって肥満や糖尿病などの原因になる。塩味の摂りすぎも血圧、心臓、腎臓への悪影響がある。このような味は実際、その美味しさのために摂りすぎることが問題となっている。これらの味の伝達物質について、神経生理学的手法を用いて明らかにすることが本研究課題の目的であるが、それは生活習慣病の成因とも関連する栄養情報の味物質と塩味物質の摂取に関与する経路を明らかにすることでもあり、摂食調節への味覚の役割を明らかにする上で欠かせない。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (42 results)

All 2019 2018 2017 2016 2015 Other

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (32 results) (of which Int'l Joint Research: 10 results,  Invited: 16 results) Remarks (4 results)

  • [Journal Article] Fatty acid taste quality information via GPR120 in the anterior tongue of mice2018

    • Author(s)
      Yasumatsu Keiko、Iwata Shusuke、Inoue Mayuko、Ninomiya Yuzo
    • Journal Title

      Acta Physiologica

      Volume: 226 Issue: 1

    • DOI

      10.1111/apha.13215

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Role of Cholecystokinin in Peripheral Taste Signaling in Mice2017

    • Author(s)
      Yoshida Ryusuke、Shin Misa、Yasumatsu Keiko、Takai Shingo、Inoue Mayuko、Shigemura Noriatsu、Takiguchi Soichi、Nakamura Seiji、Ninomiya Yuzo
    • Journal Title

      Frontiers in Physiology

      Volume: 8 Pages: 866-866

    • DOI

      10.3389/fphys.2017.00866

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] マウスの脂肪酸に対する行動応答および神経応答の解析2017

    • Author(s)
      安松啓子、岩田周介、井上真由子、二ノ宮裕三
    • Journal Title

      日本味と匂学会誌

      Volume: 24 Pages: 35-38

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] アンジオテンシンIIのT1Rs非依存的甘味応答に及ぼす影響2017

    • Author(s)
      岩田周介、安松啓子、井上真由子、吉田竜介、重村憲徳、二ノ宮裕三
    • Journal Title

      日本味と匂学会誌

      Volume: 24 Pages: 31-34

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Modulation of sweet taste sensitivities by endogenous leptin and endocannabinoids in mice.2015

    • Author(s)
      Niki M, Jyotaki M, Yoshida R, Yasumatsu K, Shigemura N, DiPatrizio NV, Piomelli D, Ninomiya Y.
    • Journal Title

      J Physiol.

      Volume: Feb 25 Issue: 11 Pages: 1-48

    • DOI

      10.1113/jp270295

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glucagon like peptide-1 is specifically involved in sweet taste transmission2015

    • Author(s)
      Shingo Takai, Keiko Yasumatsu, Mayuko Inoue Shusuke Iwata, Ryusuke Yoshida, Noriatsu Shigemura, Yuchio Yanagawa, Daniel J. Drucker, Robert F. Margolskee, Yuzo Ninomiya
    • Journal Title

      The FASEB Journal

      Volume: Vol. 29 Issue: 6 Pages: 1-13

    • DOI

      10.1096/fj.14-265355

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Novel taste sensory pathways for sugars and fatty acids in the mouse periphery.2019

    • Author(s)
      Ninomiya Y, Yasumatsu K, Iwata S, Yoshida R
    • Organizer
      the 9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Fatty acid-responding neurons in mouse glossopharyngeal nerve.2019

    • Author(s)
      Yasumatsu K, Iwata S, Inoue M, Ninomiya Y
    • Organizer
      the 9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Adrenomedullin enhances chorda tympani nerve responses to sugars in mice.2019

    • Author(s)
      Iwata S, Inoue M, Yasumatsu K, Yoshida R, Ninomiya Y
    • Organizer
      the 9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019)
    • Related Report
      2018 Annual Research Report
  • [Presentation] マウス舌咽神経における脂肪酸に対する単一神経応答の解析2018

    • Author(s)
      安松啓子,岩田周介,二ノ宮裕三
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] アドレノメデュリンによるマウス鼓索神経応答への影響2018

    • Author(s)
      岩田周介,安松啓子,吉田竜介,二ノ宮裕三
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Roles of sugar transporters and calorie sensors in taste cells.2018

    • Author(s)
      Ninomiya Y, Yasumatsu K, Yoshida R, Iwata S, Shigemura N
    • Organizer
      ECRO2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] マウス舌咽神経単一神経記録による脂肪酸受容機構の解析2018

    • Author(s)
      安松啓子,岩田周介,井上真由子,二ノ宮裕三
    • Organizer
      日本味と匂学会第52回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] アドレノメデュリンのマウス鼓索神経応答への影響2018

    • Author(s)
      岩田周介,安松啓子,井上真由子,吉田竜介,二ノ宮裕三
    • Organizer
      日本味と匂学会第52回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脂肪酸の感覚を伝えるためのGタンパク共役型受容体とマウス鼓索神経における神経コーディング2017

    • Author(s)
      安松啓子、二ノ宮裕三
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松市
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 口腔脳腸機能分子連関:グルコース輸送体を介する甘味受容伝達経路2017

    • Author(s)
      二ノ宮裕三、中野(安松)啓子、大栗弾宏、岩田周介、高井信吾、吉田竜介、重村憲徳、Margolskee RF
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松市
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Multiple sweet taste signaling pathways in the mouse periphery.2017

    • Author(s)
      Ninomiya Y, Yasumatsu K, Yoshida R, Takai S, Iwata S, Sanematsu K, Shigemura N, Margolskee RF.
    • Organizer
      AChemS2017, Bonita Springs, USA
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular, cellular and neural analyses of multiple sweet signaling pathways in the mouse periphery.2017

    • Author(s)
      Ninomiya Y, Yasumatsu K, Yoshida R, Iwata S, Takai S, Shigemura N.
    • Organizer
      37th Blankenese Conferences, Hamburg, German
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Analyses of taste information pathways for fatty acids by neural and behavioral response measurements in mice2017

    • Author(s)
      Yasumatsu K, Iwata S, Inoue M, Ninomiya Y.
    • Organizer
      27th ECRO, Cambridge, UK
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 口腔内の脂肪センシングメカニズムと今後の医療への期待2017

    • Author(s)
      安松-中野啓子
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] カプサイシンによるマウス鼓索神経応答への影響2017

    • Author(s)
      岩田周介、安松啓子、二ノ宮裕三
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 塩味感受性とその可変性2017

    • Author(s)
      重村憲徳、吉田竜介、實松敬介、高井信吾、岩田周介、安松啓子、二ノ宮裕三
    • Organizer
      日本味と匂学会第51回大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] マウスの脂肪酸に対する行動応答および神経応答の解析2017

    • Author(s)
      安松啓子、岩田周介、井上真由子、二ノ宮裕三
    • Organizer
      日本味と匂学会第51回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] アンジオテンシンIIのT1Rs非依存的甘味応答におよぼす影響2017

    • Author(s)
      岩田周介、安松啓子、井上真由子、吉田竜介、重村憲徳、二ノ宮裕三
    • Organizer
      日本味と匂学会第51回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Information pathways for fatty acids via GPR120 in mouse chorda tympani nerve.2017

    • Author(s)
      Yasumatsu K, Iwata S, Inoue M, Ninomiya Y.
    • Organizer
      The 16th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception.
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Sweet taste information via SGLT1 in the mouse chorda tympani and glossopharyngeal nerves2016

    • Author(s)
      Yasumatsu (Nakano) K, Iwata S, Ohkuri T, Shigemura N, Margolskee RF, Ninomiya Y
    • Organizer
      Annual Scientific meeting of Monell Chemical Senses Center 2016
    • Place of Presentation
      Pennsylvania, USA
    • Year and Date
      2016-10-31
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] マウス鼓索神経・舌咽神経におけるSGLT1を介する甘味情報2016

    • Author(s)
      安松啓子、岩田周介、大栗弾宏、重村憲徳、二ノ宮裕三
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-08-24
    • Related Report
      2016 Research-status Report
  • [Presentation] Gustatory responses of taste receptor cells expressing fluorescent proteins in transgenic mice2016

    • Author(s)
      Yoshida R, Yasumatsu-Nakano K, Sanematsu K, Shigemura N, Ninomiya Y
    • Organizer
      17th International Symposium on Olfaction and Taste (ISOT2016).
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-05
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Glucagon like peptide-1, sweet taste and metabolic modulation of peripheral taste information2016

    • Author(s)
      Takai S, Shigemura N, Yasumatsu-Nakano K, Inoue M, Iwata S, Yoshida R, Margolskee RF, Ninomiya Y
    • Organizer
      17th International Symposium on Olfaction and Taste (ISOT2016).
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-05
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Analysis of sweet taste responses via SGLT1 in the mouse chorda tympani and glossopharyngeal nerves2016

    • Author(s)
      Yasumatsu -Nakano K, Ito Y, Ohkuri T, Iwata S, Margolskee RF, Ninomiya Y
    • Organizer
      17th International Symposium on Olfaction and Taste (ISOT2016).
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-05
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Molecular mechanisms to generate the diversity of taste cells2016

    • Author(s)
      Matsumoto I, Ohmoto M, Lees J, Yasumatsu (Nakano) K, Ninomiya Y
    • Organizer
      ISOT Satellite Symposium on Taste: Basic Tastes and Moreover.
    • Place of Presentation
      東京
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 味覚神経研究:研究手法とストラテジー2016

    • Author(s)
      安松(中野) 啓子
    • Organizer
      東京農業大学生体環境解析学特別講演
    • Place of Presentation
      東京
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] うま味受容細胞から神経への伝達物質の解明2015

    • Author(s)
      中野(安松) 啓子
    • Organizer
      第20回うま味研究助成成果発表会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-27
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] ホルモンによる味覚(塩味・甘味)感受性調節2015

    • Author(s)
      重村憲徳、吉田竜介、安松啓子、大栗弾宏、岩田周介、髙井信吾、上瀧将史、仁木麻由、實松敬介、二ノ宮裕三
    • Organizer
      第67回日本生物工学会大会
    • Place of Presentation
      鹿児島
    • Year and Date
      2015-10-26
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] マウス鼓索神経における脂肪酸応答単一神経の記録2015

    • Author(s)
      安松啓子、吉田竜介、實松敬介、重村憲徳、二ノ宮裕三
    • Organizer
      日本味と匂学会第49回大会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-09-24
    • Related Report
      2015 Research-status Report
  • [Presentation] エンドカンナビノイドレセプターを介した自己増幅的な甘味応答の増強とT1R3非依存性甘味受容経路2015

    • Author(s)
      岩田周介、吉田竜介、安松啓子、重村憲徳、二ノ宮裕三
    • Organizer
      日本味と匂学会第49回大会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-09-24
    • Related Report
      2015 Research-status Report
  • [Presentation] マウスは市販オレンジジュースの味を弁別できるか2015

    • Author(s)
      森田麻希、目片志亜、山村知暉、山本梨乃、牧野智咲、川村早苗、安松啓子、硲 哲崇
    • Organizer
      日本味と匂学会第49回大会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-09-24
    • Related Report
      2015 Research-status Report
  • [Presentation] マウス鼓索神経における脂肪酸に対する単一神経応答の解析2015

    • Author(s)
      安松啓子、二ノ宮裕三
    • Organizer
      第57回歯科基礎医学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
  • [Remarks] 九大広報プレスリリース: 脂肪酸が第 6 番目の基本味である証拠となる神経を新発見

    • URL

      https://www.kyushu-u.ac.jp/f/35081/19_02_05_01.pdf

    • Related Report
      2018 Annual Research Report
  • [Remarks] 研究成果: 脂肪酸が第 6 番目の基本味である証拠となる神経を新発見

    • URL

      https://www.kyushu-u.ac.jp/ja/researches/view/316

    • Related Report
      2018 Annual Research Report
  • [Remarks] 味覚・嗅覚センサ研究開発センター 原著論文

    • URL

      http://www.rdctos.kyushu-u.ac.jp/accomplishments/detail0330.html

    • Related Report
      2015 Research-status Report
  • [Remarks] 味覚の研究室 業績

    • URL

      http://www.dent.kyushu-u.ac.jp/sosiki/a06/gyouseki.htm

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2020-03-30  

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