Role of CCL2/CCL2 receptor signaling within trigeminal ganglia on the inflammatory pain

• Project/Area Number: 15K11058
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Functional basic dentistry
• Research Institution: Azabu University
• Principal Investigator: Takeda Mamoru 麻布大学, 生命・環境科学部, 教授 (20227036)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 三叉神経節 / ケモカイン / 炎症 / 痛覚過敏 / パッチクランプ / 免疫組織化学 / 逃避反射 / ＣＣＬ２ / CCL2 / CCR2

Outline of Final Research Achievements

This study investigated the functional significance of hyperalgesia in the CCL2/CCL2 receptor signaling system in trigeminal ganglion (TG) neurons following inflammation, using behavioral, immunohistochemical and electrophysiological analysis.The present study provides evidence that CCL2 enhances the excitability of small-diameter TG neurons following facial skin inflammation via the upregulation of CCL2/CCL2 receptor signaling. These findings suggest that ganglionic CCL2/CCL2 receptor signaling is a therapeutic molecular target for the treatment of trigeminal inflammatory hyperalgesia.

Research Products

• [Journal Article] Chemiokine ligand 2/chemokine receptor 2 signaling in the trigeminal ganglia contributes to inflammatory hyperalgesia in rats (2018)
  • Author(s): Takeda M, Nasu M, Kanazawa T, Takahashi M, Shimazu Y
  • Journal Title: Neuroscience Research Volume: 128 Pages: 25-32
  • Peer Reviewed