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Association of stemness preservation with oncogenesis of odontogenic epithelium within the intraosseous microenvironment

Research Project

Project/Area Number 15K11066
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionTohoku University

Principal Investigator

KUMAMOTO HIROYUKI  東北大学, 歯学研究科, 教授 (70215028)

Co-Investigator(Kenkyū-buntansha) 清水 良央  東北大学, 歯学研究科, 助教 (30302152)
及川 麻理子  東北大学, 歯学研究科, 助教 (00712902)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords歯原性腫瘍 / 腫瘍発生 / 骨内進展
Outline of Final Research Achievements

Regulator molecules associated with hypoxic condition, cell development, proliferation, and differentiation were examined to clarify the effect of stemness preservation in oncogenesis of odontogenic epithelium under the intraosseous microenvironment. Hypoxia-related molecules, HIF-1 and CA IX, were greater in ameloblastoma than in tooth germ, and solid ameloblastoma showed high reactivity as compared with unicystic ameloblastoma. Measurement of CD34-positive microvessels were correlated positively with HIF-1 and CA IX. Cell proliferation signaling pathways , MAPK, Akt, and STAT3, were activated in ameloblastoma rather than tooth germ, and BRAF mutations were detected only in ameloblastoma but not in tooth germ. Translocation of cell development-related gene EWSR1 was confirmed in clear cell odontogenic carcinoma but not in other celar cell tumors by FISH method.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (34 results)

All 2018 2017 2016 2015

All Journal Article (20 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 20 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (11 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results) Book (3 results)

  • [Journal Article] Immunohistochemicalassessment of hypoxia-inducible factor-1α (HIF-1α) and carbonic anhydrase IX (CA IX) in ameloblastomas2018

    • Author(s)
      Arima Y Oikawa M Shimizu Y Echigo S Takahashi T Kumamoto H
    • Journal Title

      J Oral Maxillofac Surg Med Pathol

      Volume: 30

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peripheral clear cell variant of calcifying epithelial odontogenic tumor devoid of calcification2018

    • Author(s)
      Kurihara A Mori S Oikawa M Kumamoto H Takahashi T
    • Journal Title

      J Oral Sci

      Volume: 15

    • NAID

      130007487194

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of immunoregulatory molecules PD-L1 and PD-1 in oral cancer and precancerous lesions: A cohort study of Japanese patients2018

    • Author(s)
      Kouketsu A Sato I Oikawa M Shimizu Y Saito H Takahashi T Kumamoto H
    • Journal Title

      J Craniomaxillofac Surg

      Volume: 46 Issue: 1 Pages: 33-40

    • DOI

      10.1016/j.jcms.2017.04.013

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 下顎に発生した周辺性象牙質形成性幻影細胞腫の1例2017

    • Author(s)
      神田直典 及川麻理子 廣谷拓章 川井忠 熊本裕行 髙橋哲
    • Journal Title

      日口外誌

      Volume: 63 Pages: 251-256

    • NAID

      130005815211

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 口腔癌(口腔扁平上皮癌)とその前駆病変の組織診断と分子病理2017

    • Author(s)
      熊本裕行
    • Journal Title

      東北歯誌

      Volume: 35-36 Pages: 1-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnostic performance of MR imaging of three major salivary glands for Sjögren's syndrome.2017

    • Author(s)
      I Kojima I, M Sakamoto , M Iikubo , H Kumamoto, A Muroi, Y Sugawara, S Satoh-Kuriwada, T Sasano
    • Journal Title

      Oral diseases  2017 Jan;23(1):84-90

      Volume: 23 Issue: 1 Pages: 84-90

    • DOI

      10.1111/odi.12577

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Underlying Mechanisms and Therapeutic Strategies for Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ)2017

    • Author(s)
      Endo Y, Kumamoto H, Nakamura M, Sugawara S, Takano-Yamamoto T, Sasaki K, Takahashi T
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 40 Issue: 6 Pages: 739-750

    • DOI

      10.1248/bpb.b16-01020

    • NAID

      130005688081

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Experimental comparison between tractional and compressive stress on temporomandibular joint2017

    • Author(s)
      Nogami S Yamauchi K Shimizu Y Hirayama B Kumasaka A Iikubo M Kumamoto H Takahashi T
    • Journal Title

      Oral Dis

      Volume: 23 Issue: 5 Pages: 644-652

    • DOI

      10.1111/odi.12650

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Induction of the Histamine-Forming Enzyme Histidine Decarboxylase in Skeletal Muscles by Prolonged Muscular Work: Histological Demonstration and Mediation by Cytokines2017

    • Author(s)
      Ayada K, Tsuchiya M, Yoneda H, Yamaguchi K, Kumamoto H, Sasaki K, Tadano T, Watanabe M, Endo Y.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 40 Issue: 8 Pages: 1326-1330

    • DOI

      10.1248/bpb.b17-00112

    • NAID

      130005876320

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Roles of Aryl Hydrocarbon Receptor in Aromatase-Dependent Cell Proliferation in Human Osteoblasts2017

    • Author(s)
      Miki Yasuhiro、Hata Shuko、Ono Katsuhiko、Suzuki Takashi、Ito Kiyoshi、Kumamoto Hiroyuki、Sasano Hironobu
    • Journal Title

      International Journal of Molecular Sciences.

      Volume: 18 Issue: 10 Pages: 2159-2159

    • DOI

      10.3390/ijms18102159

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Underlying mechanisms and therapeutic strategies for bisphosphonate-related osteinecrosis of the jaw (BRONJ)2017

    • Author(s)
      Endo Y Kumamoto H Nakamura M Sugawara S Takano-Ymamoto T Sasaki K Takahashi T
    • Journal Title

      Biol Pharm Bull

      Volume: 40

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 歯原性腫瘍の病理診断2016

    • Author(s)
      熊本裕行
    • Journal Title

      東北歯誌

      Volume: 34/35 Pages: 1-12

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Radicular cyst associated with anomalous tooth, suspicious of dens invaginatus: report of two cases2016

    • Author(s)
      Kataoka Y Yamauchi K Saito M Nogami S Yamaguchi Y Saito H Kumamoto H Takahashi T
    • Journal Title

      J Oral Maxillofac Surg Med Pathol

      Volume: 28 Pages: 375-379

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Detection of human papillomavirus infection in oral squamous cell carcinoma: a cohort study of Japanese patients2016

    • Author(s)
      Kouketsu A Sato I Abe S Oikawa M Shimizu Y Takahashi T Kumamoto H
    • Journal Title

      J Oral Pathol Med

      Volume: 45 Issue: 8 Pages: 565-572

    • DOI

      10.1111/jop.12416

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Immunohistochemical and genetic evaluations of epidermal growth factor receptor (EGFR) in oral squamous cell carcinoma2016

    • Author(s)
      Abe S Oikawa M Miki Y Shimizu Y Suzuki T Takahashi T Kumamoto H
    • Journal Title

      J Oral Maxillofac Surg Med Pathol

      Volume: 28 Pages: 174-181

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Quantitative analysis of nuclear shape in oral squamous cell carcinoma is useful for predicting the chemotherapeutic response2016

    • Author(s)
      Ogura M Yamamoto Y Miyashita H Kumamoto H Fukumoto M
    • Journal Title

      Med Mol Morphol

      Volume: 49 Issue: 2 Pages: 76-82

    • DOI

      10.1007/s00795-015-0121-4

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Timed-release system for periosteal expansion osteogenesis using NiTi mesh and absorbable material in the rabbit calvaria2016

    • Author(s)
      Yamauchi K Nogami S Martinez-de la Cruz G Hirayama B Shimizu Y Kumamoto H Lethaus B Kessler P Takahashi T
    • Journal Title

      J Craniomaxillofac Surg

      Volume: 44 Issue: 9 Pages: 1366-1372

    • DOI

      10.1016/j.jcms.2016.06.015

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Steroid and xenobiotic receptor-mediated effects of bisphenol A on human osteoblasts.2016

    • Author(s)
      Miki Y, Hata S, Nagasaki S, Suzuki T, Ito K, Kumamoto H, Sasano H.
    • Journal Title

      Life Sci.

      Volume: 155 Pages: 29-35

    • DOI

      10.1016/j.lfs.2016.05.013

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] In vivo corrosion behaviour of magnesium alloy in association with surrounding tissue response in rats2016

    • Author(s)
      Miura C Shimizu Y Imai Y Mukai T Yamamoto A Sano Y Ikeo N Isozaki S Takahashi T Oikawa M Kumamoto H Tachi M
    • Journal Title

      Biomedical Materials

      Volume: 11 Issue: 2 Pages: 025001-025001

    • DOI

      10.1088/1748-6041/11/2/025001

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 歯原性腫瘍の病理診断2015

    • Author(s)
      熊本裕行
    • Journal Title

      東北歯誌

      Volume: 34

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] アジアにおける歯原性腫瘍の実態に関する大規模共同調査研究2017

    • Author(s)
      髙田隆 仙波伊知郎 前田初彦 武田泰典 熊本裕行 久山佳代 豊澤悟 長塚仁 宮内睦美 小川郁子
    • Organizer
      第106回日本病理学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 診断に苦慮した下顎前歯部石灰化嚢胞性歯原性腫瘍の1例2017

    • Author(s)
      纐纈衆 後藤哲 樋口景介 相場信彦 熊本裕行 髙橋哲
    • Organizer
      第43回日本口腔外科学会北日本支部学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 口腔癌および前癌病変におけるEph/Ephrin系の分子発現に関する免疫組織化学的検討2017

    • Author(s)
      齊藤博紀 及川麻理子 纐纈衆 清水良央 髙橋哲 熊本裕行
    • Organizer
      第62回日本口腔外科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 口腔扁平上皮癌および前癌病変における制御性T細胞およびM2腫瘍随伴マクロファージの関与に関する臨床病理学的研究2017

    • Author(s)
      纐纈衆 及川麻理子 清水良央 髙橋哲 熊本裕行
    • Organizer
      第35回日本口腔腫瘍学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 口腔扁平上皮癌とその前駆病変の病理診断2016

    • Author(s)
      熊本裕行
    • Organizer
      第5回宮城県口腔外科研究会総会・講演会
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-03
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] エナメル上皮腫における細胞内増殖シグナル伝達分子の検討2016

    • Author(s)
      及川麻理子 佐藤郁郎 纐纈衆 清水良央 熊本裕行
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2016-05-13
    • Related Report
      2016 Research-status Report 2015 Research-status Report
  • [Presentation] エナメル上皮腫における低酸素分子HIF-1alpha、CA IXに関する免疫組織化学的検討2016

    • Author(s)
      有馬良季 及川麻理子 清水良央 越後成志 髙橋哲 熊本裕行
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2016-05-13
    • Related Report
      2016 Research-status Report
  • [Presentation] 口腔癌・前癌病変の分子病理とその臨床応用2016

    • Author(s)
      熊本裕行
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2016-05-13
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] エナメル上皮腫におけるHIF-1, CA IX,の免疫組織化学的解析2016

    • Author(s)
      有馬良季 及川麻理子 清水良央 越後成志 髙橋哲 熊本裕行
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2016-05-13
    • Related Report
      2015 Research-status Report
  • [Presentation] Odontogenic tumors2015

    • Author(s)
      Kumamoto H
    • Organizer
      Workshop Nasional I Ikatan Spesialis Pathologi Mulut Dan Maksilfasial Indonesia (ISPaMMI)
    • Place of Presentation
      Surabaya
    • Year and Date
      2015-11-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 歯原性腫瘍の病理診断2015

    • Author(s)
      熊本裕行
    • Organizer
      第26回日本臨床口腔病理学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2015-07-29
    • Related Report
      2015 Research-status Report
    • Invited
  • [Book] 口腔病理アトラス 第3版2018

    • Author(s)
      高木實 監 高田隆・豊澤悟 編 熊本裕行 分担執筆
    • Total Pages
      380
    • Publisher
      文光堂
    • ISBN
      9784830670046
    • Related Report
      2017 Annual Research Report
  • [Book] 新口腔病理学 第2版2018

    • Author(s)
      下野正基・高田隆・田沼順一・豊澤悟 編 熊本裕行 分担執筆
    • Total Pages
      359
    • Publisher
      医歯薬出版
    • ISBN
      9784263458150
    • Related Report
      2017 Annual Research Report
  • [Book] 頭頸部腫瘍II2015

    • Author(s)
      熊本裕行(森永正二郎 高田隆 長尾俊孝編)
    • Total Pages
      301
    • Publisher
      文光堂
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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