| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
We administered green tea catechin (epigallocatechin gallate; EGCG) to MRL-Fas (lpr) mice and examined suppressive effects of EGCG on autoimmune sialadenitis. Our results demonstrated that expression of aquaporin 5 (AQP5) at apical plasma membrane of submandibular gland acinic cells and that of protein kinase A (PKA) which promotes AQP5 production increased significantly compared with non-EGCG treated mice. Meanwhile, EGCG-treated mice displayed reduced expression of nuclear factor- κB (NF-κB) and its activator, c-Jun N-terminal kinase (JNK) and high-mobility group box-1 (HMGB1) as well as receptor for advanced glycation end products (RAGE) which are receptors of HMGB1 compared with non-EGCG treated mice. Taken together, our study show that EGCG serves as a salivary secretagogue in autoimmune sialadenitis.
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