Elucidation of chronic inflammation exacerbation mechanism due to breakdown of endo-lysosomal proteolysis
Project/Area Number |
15K11079
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pathobiological dentistry/Dental radiology
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Research Institution | Nagasaki University |
Principal Investigator |
KADOWAKI Tomoko 長崎大学, 医歯薬学総合研究科(歯学系), 准教授 (70336080)
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Co-Investigator(Kenkyū-buntansha) |
筑波 隆幸 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (30264055)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | 生体応答 / エンドソーム / リソソーム / タンパク質分解 / 細胞内輸送 |
Outline of Final Research Achievements |
Dental diseases such as periodontal disease, apical periodontitis, and Sjogren's syndrome often exhibit intractable chronic inflammation. The aim of this study is to show that abnormal endo-lysosomal proteolysis causes accumulation of internal irritants as a cause of chronic inflammation, which leads to prolonged and severe inflammation We found that deficiency of protease causes chronic inflammation and dysfunction of macrophage and adipose tissue differentiation. This study is not limited to chronic inflammation which accounts for the majority of oral diseases, and it clarifies one aspect of the chronic mechanism of systemic inflammation.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Sanguiin H-6, a constituent of Rubus parvifolius L., inhibits receptor activator of nuclear factor-κB ligand-induced osteoclastogenesis and bone resorption in vitro and inhibits tumor necrosis factor-α-induced osteoclastogenesis in vivo.2016
Author(s)
Sakai E, Aoki Y, Yoshimatsu M, Nishishita K, Iwatake M, Fukuma Y, Okamoto K, Tanaka T, Tsukuba T
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Journal Title
Phytomedicine
Volume: 23
Issue: 8
Pages: 828-837
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] KBTBD11, a novel BTB-Kelch protein, is a negative regulator of osteoclastogenesis through controlling Cullin3-mediated ubiquitination.2017
Author(s)
Narahara S, Sakai E, Kadowaki T, Yamaguchi Y, Narahara H, Okamoto K, Sumita Y, Asahina I, Tsukuba T
Organizer
2017 ASCB | EMBO Meeting
Related Report
Int'l Joint Research
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