Molecular mechanism of inflammatory pathology through ER stress signaling in oral macrophages
| Project/Area Number |
15K11080
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NISHITOH Hideki 宮崎大学, 医学部, 教授 (00332627)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 小胞体ストレス / 炎症 / マクロファージ |
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| Outline of Final Research Achievements |
The oral cavity is exposed to various stresses such as wounds, thermal stimuli, bacterial and viral infections, and contacts with foreign bodies, and often causes refractory oral mucosal inflammation. Since oral chronic inflammation sometimes leads to the causes of oral precancerous lesions and carcinogenesis, it is significant to elucidate the pathological mechanism.
Recent studies focus on endoplasmic reticulum (ER) stress as a common intracellular phenomenon in various inflammatory diseases. Therefore, in this study, from the viewpoint of ER stress signaling, we clarify the molecular mechanisms of macrophage differentiation, activation, and apoptosis using the in vitro and in vivo inflammation model experimental systems, and aim to overcome inflammatory diseases.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Preemptive quality control protects the ER from protein overload via the proximity of ERAD components and SRP.2015
Author(s)
Kadowaki H, Nagai A, Maruyama T, Takami Y, Satrimafitrah P, Kato H, Honda A, Hatta T, Natsume T, Sato T, Kai H, Ichijo H, Nishitoh H
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Journal Title
Cell reports
Volume: 13
Issue: 5
Pages: 944-956
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] A systematic immunoprecipitation approach reinforces the concept of common conformational alterations in amyotrophic lateral sclerosis-linked SOD1 mutants.2015
Author(s)
Fujisawa T, Yamaguchi N, Kadowaki H, Tsukamoto T, Tsuburaya N, Tsubota A, Takahashi H, Naguro I, Takahashi Y, Goto J, Tsuji S, Nishitoh H, Homma K, Ichijo H
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Journal Title
Neurobiology of Disease
Volume: 82
Pages: 478-486
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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