Analysis of mechanisms related to the induction of mucosal immunity in Peyer's patches against oral vaccine

Research Project

Project/Area Number	15K11085
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Pathobiological dentistry/Dental radiology
Research Institution	Nihon University
Principal Investigator	HASHIZUME-TAKIZAWA Tomomi 日本大学, 松戸歯学部, 助教 (50419785)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	経口ワクチン / 組換え型サルモネラ / 分泌型IgA / パイエル板 / サルモネラ / Salmonella
Outline of Final Research Achievements	We assessed mechanisms of the induction of antigen (Ag)-specific intestinal secretory (S)IgA antibody (Ab) responses against orally administered vaccines in order to provide helpful information that will aid in the development of an effective mucosal vaccine. Our previous study showed that Peyer’s patches (PP) are required for the induction of Ag-specific intestinal SIgA Ab responses to oral attenuated recombinant Salmonella vaccine strain. In this study, we further showed that PP B cells play specific roles for the induction of Ag-specific mucosal IgA Ab responses in vitro.

Report

(4 results)