| Project/Area Number |
15K11087
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
浅野 正岳 日本大学, 歯学部, 教授 (10231896)
勝呂 尚 日本大学, 歯学部, 講師 (90318452)
五條堀 孝廣 日本大学, 歯学部, 助教 (10755573)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 免疫 / 感染 / 炎症 |
|---|
| Outline of Final Research Achievements |
Functional water (FW) is known to have an advantageous effect on living bodies, but there are many unclear points on the detailed mechanism. We examined how FW affects oral mucosa-derived epithelial cells. As a result, secretion of IL-1a, bFGF, EMMPRIN etc. was induced. IL-1a has an accelerating effect on wound healing. In experiments using a bone defect model, the production of angiogenic factors and cytokines involved in bone regeneration was enhanced. It was suggested that wound healing is promoted by inducing the expression of these factors.
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