Elucidation of the salivary secretion regulation mechanism through mitochondrial function control by estrogen
| Project/Area Number |
15K11091
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
斎藤 一郎 鶴見大学, 歯学部, 教授 (60147634)
井上 裕子 日本薬科大学, 薬学部, 教授 (50367306)
梁 洪淵 鶴見大学, 歯学部, 講師 (10298268)
内田 仁司 鶴見大学, 歯学部, 学内講師 (20736996)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 口腔乾燥症 / ドライマウス / 女性ホルモン / エストロゲン / ミトコンドリア / 唾液 / マウス / OVX / 唾液分泌 |
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| Outline of Final Research Achievements |
In this study, in order to clarify the involvement of estrogen in salivary secretion ability and its molecular mechanism, early menopausal mice by OVX were analyzed as model animals. Salivary secretion decreased with OVX decrease of blood estrogen concentration, and model animal of xerostomia in menopause could be constructed. Furthermore, supplementation of estrogen improved the amount of saliva secretion and acinar shrinkage, and it was shown that estrogen is greatly related to the salivary secretion ability of the salivary glands. As a mechanism of this phenomenon, focusing on the control of mitochondrial function by estrogen, we analyzed mitochondrial function and others. As a result, it was suggested that a qualitative change in mitochondria, probably a change in morphology, accompanying the change in the amount of estrogen occurred.
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Report
(4 results)
Research Products
(2 results)
