| Project/Area Number |
15K11094
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Asahi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
村上 幸孝 朝日大学, 歯学部, 教授 (60239506)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 歯周病関連細菌 / 自然免疫 / 血清抵抗性 / 糖修飾 / 外膜タンパク質 / 歯肉線維芽細胞 / Toll-like receptor / Porphyromonas gingivalis / Tannerella forsythia / OmpA様蛋白質 / 細胞付着・刺激性 / 細胞付着 |
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| Outline of Final Research Achievements |
Porphyromonas gingivalis (Pg) and Tannerella forsythia (Tf), which are representative periodontopathic bacteria, have OmpA-like proteins (OmpALPs) as outer-membrane proteins, but the involvement of OmpALPs in the pathogenicity has not been clarified. This research revealed that Pg-derived OmpALP is involved in serum resistance and host cell stimulation, and the sugar modification of Tf-derived OmpALP.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の実施によって、今まで理解されてこなかった歯周病関連細菌の有する主要な外膜蛋白質の宿主に及ぼす影響、すなわち病原性を明らかにすることができたと考える。得られた研究成果は、腸内細菌のOmpA蛋白質にも反映すると考えられるため、歯科医学のみならず、基礎医科学・生物学においても有益な知見となると思われる。
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