Antitumor immunities with low dose / low dose rate radiation on murine model with oral squamous cell carcinoma
| Project/Area Number |
15K11096
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Asahi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
一戸 辰夫 広島大学, 原爆放射線医科学研究所, 教授 (80314219)
佐藤 あやの 岡山大学, 自然科学研究科, 准教授 (40303002)
増田 潤子 岡山大学, 自然科学研究科, 特任助教 (20424674)
近藤 信夫 朝日大学, 歯学部, 教授 (40202072)
川木 晴美 朝日大学, 歯学部, 准教授 (70513670)
神谷 真子 朝日大学, 経営学部, 准教授 (80181907)
梅村 直己 朝日大学, 歯学部, 助教 (80609107)
中田 隆博 常葉大学, 健康プロデュース学部, 教授 (40273932)
本庶 仁子 広島大学, 原爆放射線医科学研究所, 講師 (80614106)
足立 誠 朝日大学, 歯学部, 講師 (10468192)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 腫瘍 / 放射線 / 免疫 / T細胞 / サイトカイン |
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| Outline of Final Research Achievements |
Syngeneic mouse subcutaneous and pulmonary tumor models by local subcutaneous and intravenous injection of colon carcinoma CT26 cells were established. Myeloid-derived suppressor cell (MDSC) were significantly increased in the subcutaneous tumor model, but not the pulmonary model. Both CD4+ and CD8+ T cells as well as CD4+ Foxp3+ T cells were significantly decreased in the subcutaneous tumor model, but not the pulmonary model. In addition, the subcutaneous model, but not the pulmonary model, displayed a Th1 polarization bias. This bias was characterized by decreased IL-4,IL-9, and IL-10 production, whereas the pulmonary model displayed increased production of IL-10. These results suggest that the mode of tumor development has differential effects on systemic immunity that may, in turn, influence approaches to treatment of cancer patients.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Tumor growth limited to subcutaneous site vs tumor growth in pulmonary site exhibit differential effects on systemic immunities2017
Author(s)
Masuda J, Takayama E, Strober W, Satoh A, Morimoto Y, Honjyo Y, Ichinose T, Tokuno SI, Ishizuka T, Nakata T, Mizutani A, Umemura N, Kitani A, Fuss IJ, Shigehiro T, Kawaki H, Mizuno-Kamiya M, Kondoh N, Seno M.
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Journal Title
Oncol Rep.
Volume: 38
Pages: 449-455
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Tumor growth limited to a single site vs tumor growth in multiple sites exhibit differential effects on systemic immunities.2017
Author(s)
Masuda J, Takayama E, Strober W, Satoh A, Morimoto Y, Honjo Y, Ichinohe T, Tokuno S, Ishizuka T, Nakata T, Mizutani A, Umemura N, Kitani A, Fuss IJ, Shigehiro T, Kawaki H, Mizuno-Kamiya M, Kondoh N, Seno M.
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Journal Title
Oncology Reports, 印刷中.
Volume: 印刷中
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Immunosuppression Effect by Adipose Tissue-derived Mesenchymal Stem Cells Isolated from β2-microglobulin Deficient mice.2017
Author(s)
Masuda J, Takayama E, Ichinohe T, Strober W, Mizuno-Kamiya M, Ikawa T, Kitani A, Kawaki H, Fuss IJ, Kawamoto H, Seno A, Vaidyanath A, Umemura N, Mizutani A, Kasai T, Honjo Y, Satoh A, Murakami H, Katsura Y, Kondoh N, Seno M.
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Journal Title
Experimental and Therapeutic Medicine
Volume: 印刷中
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Gene expression analyses associated with malignant phenotypes of metastatic subclones derived from a mouse oral squamous cell carcinoma cell line, Sq-1979.2017
Author(s)
Adachi M, Mizuno-Kamiya M, Takayama E, Kawaki H, Umemura N, Inagaki T, Sumi S, Motohashi M, Muramatsu Y, Sumitomo S, Shikimori M, Yamazaki Y, Kondoh N.
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Journal Title
Oncology Letters, 印刷中.
Volume: 印刷中
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Transient Tcf3 Gene Repression by TALE-Transcription Factor Targeting2017
Author(s)
Masuda J, Kawamoto H, Strober W, Takayama E, Mizutani A, Murakami H, Ikawa T, Kitani A, Maeno N, Shigehiro T, Satoh A, Seno A, Arun V, Kasai T, Fuss IJ, Katsura Y, Seno M
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Journal Title
Appl Biochem Biotechnol.
Volume: 180
Pages: 1559-1573
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Promotion of Nickel (Ni) Allergy by Anamnestic Sensitization with a Bacterial Component, Lipopolysaccharide (LPS), in Mice.2016
Author(s)
Adachi N, Takayama E, Adachi M, Mizuno-Kamiya M, Kawaki H, Takeuchi H, Kubo S, Ishigami H, Kurachi M, Kondoh N.
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Journal Title
The Open Dentistry Journal
Volume: 10
Pages: 531-537
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] がんモデル動物を用いた悪性度の違いによる全身免疫能変化の解析2015
Author(s)
増田潤子, 高山英次, 佐藤あやの, 守本祐司, 本庶仁子, 石塚俊晶, 徳野慎一, 青笹季文, 光吉俊二, 重廣司, 前野成実, 村上宏, 笠井智成, 水谷 昭文, Arun Vaidyanath, 妹尾 彬正, 川木晴美, 神谷(水野) 真子, 近藤信夫, 一瀬雅夫, 一戸辰夫, 妹尾昌治.
Organizer
第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会
Place of Presentation
神戸
Year and Date
2015-12-01
Related Report
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