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Analysis of Gorlin syndrome derived benign or malignant tumor

Research Project

Project/Area Number 15K11098
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionHyogo Medical University

Principal Investigator

Nakano Yoshiro  兵庫医科大学, 医学部, 教授 (30360267)

Co-Investigator(Kenkyū-buntansha) 玉置 知子 (橋本知子)  兵庫医科大学, 医学部, 名誉教授 (10172868)
山西 清文  兵庫医科大学, 医学部, 教授 (10182586)
岸本 裕充  兵庫医科大学, 医学部, 教授 (30291818)
野口 一馬  兵庫医科大学, 医学部, 准教授 (50309473)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsGorlin症候群 / 角化嚢胞性歯原性腫瘍 / hedgehog情報伝達 / PTCH1 / SMO / 基底細胞癌 / Hedgehog情報伝達系 / 分化誘導 / Hedgehog / 角化嚢胞性歯原性腫瘍(KCOT) / 分化
Outline of Final Research Achievements

Gorlin syndrome is a dominantly inherited autosomal disease with a high frequency of tumor induction caused by the hedgehog receptor PTCH1. We analyzed PTCH1 and SMO alternation in Gorlin syndrome-associated tumors, such as malignant basal cell carcinoma, benign keratocystic odontogenic tumor (KCOT), and ovarian fibroma, revealing that the mutational status of PTCH1 or SMO itself does not account for differences in malignancy and tissue-specificity of these tumors.
KCOT is the most frequent benign tumor in Gorlin syndrome patients. We established KCOT cell lines from sporadic and Gorlin syndrome-derived KCOTs. Both lines showed stem and mesenchymal cell characteristics. However, in the presence of calcium, cells showed parakeratosis and epithelial or keratinocyte-related proteins were induced. These features were similar to those of in vivo KCOTs. Using these cell lines and 3-D hydrogel culture, we may be able to advance understanding of the nature and origin of KCOTs.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (19 results)

All 2017 2016 2015

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Acknowledgement Compliant: 1 results,  Open Access: 1 results) Presentation (13 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results)

  • [Journal Article] Molecular Analysis of keraticystic odontogenic tumor cell lines derived from sporadic and basal cell nevus syndrome patients.2017

    • Author(s)
      Kazuma Noguchi, Keiko Wakai, Tohru Kiyono, Mutsuki Kawabe, Kyohei Yoshikawa, Tomoko Hashimoto-Tamaoki, Hiromitsu Kishimoto, Yoshiro Nakano.
    • Journal Title

      International Journal of Oncology

      Volume: 51 Issue: 6 Pages: 1731-38

    • DOI

      10.3892/ijo.2017.4146

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 多数歯の根吸収を伴った腺腫様歯原性腫瘍の1例2017

    • Author(s)
      芝辻豪士, 野口一馬, 山根木康嗣, 岸本裕充, 足立了平.
    • Journal Title

      日本口腔科学会雑誌

      Volume: 66(2) Pages: 137-137

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 全身および口腔内に多発したカポジ肉腫の1例2017

    • Author(s)
      野口一馬,川邊睦記,山根木康嗣,高岡一樹,岸本裕充
    • Journal Title

      日本口腔腫瘍学会誌

      Volume: 29 Pages: 15-21

    • NAID

      130005465149

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genomic profiling of the genes on chromosome 3p in sporadic clear cell renal cell carcinoma.2016

    • Author(s)
      Togo Y, Yoshikawa Y, Suzuki T, Nakano Y, Kanematsu A, Zozumi M, Nojima M, Hirota S, Yamamoto S, Hashimoto-Tamaoki T.
    • Journal Title

      Int J Oncol.

      Volume: 48 Issue: 4 Pages: 1571-80

    • DOI

      10.3892/ijo.2016.3395

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] ヘッジホッグシグナルと口腔疾患2016

    • Author(s)
      野口 一馬, 岸本 裕充, 中野 芳朗.
    • Journal Title

      口腔組織培養学会誌

      Volume: 25 Pages: 1-7

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The Hippo pathway transcriptional co-activator, YAP, confers resistance to cisplatin in human oral squamous cell carcinoma.2015

    • Author(s)
      Yoshikawa K, Noguchi K, Nakano Y, Yamamura M, Takaoka K, Hashimoto-Tamaoki T, Kishimoto H.
    • Journal Title

      Int J Oncol

      Volume: 46 Issue: 6 Pages: 2364-2370

    • DOI

      10.3892/ijo.2015.2948

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Evolution and function of sterol sensing domain protein patched-related(PTR).2017

    • Author(s)
      Nakano Yoshiro
    • Organizer
      Annual Meeting of the Japanese Society of Developmental Biologists 50th
    • Related Report
      2017 Annual Research Report
  • [Presentation] Establishment and molecular analysis of immortalized keratocystic odontogenic tumor cell lines derived from sporadic and Gorlin syndrome patients.2017

    • Author(s)
      Nakano Yoshiro, Noguchi Kazuma, Kishimoto Hiromitsu, Hashimoto-Tamaoki Tomoko.
    • Organizer
      18th International Congress of Developmental Biology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 口腔扁平上皮癌培養細胞におけるVEGF-A/VEGFRの発現2017

    • Author(s)
      荒木華子、野口一馬、上田美帆、川邊睦記、吉川恭平、高岡一樹、岸本裕充.
    • Organizer
      第54回日本口腔組織培養学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 骨微小環境における破骨前駆細胞の分化に伴う細胞運動能の変化2017

    • Author(s)
      上田美帆、高岡一樹、前田華子、野口一馬、岸本裕充.
    • Organizer
      第54回日本口腔組織培養学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Hedgehog signaling and genetic diseases.2016

    • Author(s)
      Yoshiro Nakano, Kazuma Noguchi, Hideaki Chiyo, Ritsuko Pooh, Hiromitsu Kishimoto, Tomoko Hashimoto-Tamaoki
    • Organizer
      The 13th International Congress of Human Genetics
    • Place of Presentation
      京都国際会議場(京都府京都市)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 角化曩胞性歯原性腫瘍細胞株の樹立とカルシウムによる分化誘導2016

    • Author(s)
      中野 芳朗,野口一馬,岸本裕充,橋本-玉置知子
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2016 Research-status Report
  • [Presentation] 角化嚢胞性歯原性腫瘍におけるNOTCH1の発現から考察される腫瘍組織の性質2016

    • Author(s)
      神田修治,野口一馬,川邊睦記,高岡一樹,岸本裕充
    • Organizer
      第28回日本口腔科学会近畿地方部会
    • Place of Presentation
      大阪薬業年金会館(大阪府大阪市)
    • Related Report
      2016 Research-status Report
  • [Presentation] 口腔扁平上皮癌に対するセツキシマブ耐性機構の解析2016

    • Author(s)
      荒木華子、野口一馬、高岡一樹、岸本裕充
    • Organizer
      第53回日本口腔組織培養学会総会・学術大会
    • Place of Presentation
      石川県立美術館(石川県金沢市)
    • Related Report
      2016 Research-status Report
  • [Presentation] セツキシマブ耐性口腔扁平上皮癌培養細胞の多様性についての検討2016

    • Author(s)
      荒木華子、野口一馬、高岡一樹、岸本裕充
    • Organizer
      第61回日本口腔外科学会総会・学術大会
    • Place of Presentation
      幕張メッセ 国際会議場・国際展示場(千葉県千葉市)
    • Related Report
      2016 Research-status Report
  • [Presentation] The hedgehog signaling pathway and Keratocystic Odontogenic Tumor2015

    • Author(s)
      Nakano Yoshiro, Noguchi Kazuma, Kishimoto Hiromitu, Tamaoki Tomoko
    • Organizer
      BMB2015
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Year and Date
      2015-12-02
    • Related Report
      2015 Research-status Report
  • [Presentation] 歯科領域におけるヘッジホッグ情報伝達系関連遺伝病2015

    • Author(s)
      中野 芳朗, 野口 一馬,千代 豪昭, 夫 律子, 岸本 裕充, 玉置知子
    • Organizer
      日本人類遺伝学会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2015-10-16
    • Related Report
      2015 Research-status Report
  • [Presentation] In vitro differentiation of cells from keratocystic odontogenic tumors.2015

    • Author(s)
      Noguchi Kazuma, Kishimoto Hiromitsu, Hashimoto-Tamaoki Tomoko, Nakano Yoshiro
    • Organizer
      The EMBO Meeting 2015
    • Place of Presentation
      Birmingham (UK)
    • Year and Date
      2015-09-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 角化嚢胞性歯原性腫瘍培養細胞の細胞生物学的特性.2015

    • Author(s)
      野口 一馬,首藤 敦史,吉川 恭平,西田 倫世,頭司 雄介,森寺 邦康,高岡 一樹,岸本 裕充.
    • Organizer
      第69回日本口腔科学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2015-05-15
    • Related Report
      2015 Research-status Report
    • Invited

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Published: 2015-04-16   Modified: 2019-03-29  

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