| Project/Area Number |
15K11106
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Showa University (2016-2018)
Tokyo Medical and Dental University (2015) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
川島 伸之 東京医科歯科大学, 大学院医歯学総合研究科, 講師 (60272605)
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| Research Collaborator |
IKEDA Megumi
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 根尖性歯周炎 / カテプシンＫ / カテプシンＫ阻害 / 抗RANKL抗体 / カテプシンK |
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| Outline of Final Research Achievements |
We evaluated the effects of cathepsin K inhibitor on inflammation and bone destruction in experimentally-induced rat periapical lesions. The size of the periapical lesion, number of tartrate-resistant acid phosphatase-positive osteoclasts and major histocompatibility complex class II molecule-expressing macrophages in the experimental group decreased significantly when compared with the control group. The expression of pro-inflammatory cytokines in the experimental group was significantly suppressed when compared with the control group. These results suggest that the cathepsin K inhibitor may inhibit not only cathepsin K activity in osteoclasts but also inflammatory mediator synthesis relating to osteoclastogenesis, and these synergistic effects may be involved in the suppression of periapical lesion expansion.
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| Academic Significance and Societal Importance of the Research Achievements |
根尖性歯周炎は、根尖歯周組織に生じる炎症性骨吸収性疾患であるが、その病態の判定は困難であり、慢性化すると難治性となることも少なくない。本研究はカテプシンＫ阻害剤の抗炎症作用に着目し、根尖性歯周炎の抑制に応用しようとするものである。本研究により、薬剤によって根尖性歯周炎を抑制できる可能性が示唆されたことにより、将来的に難治性根尖性歯周炎を速やかに治癒に導く可能性が開ければ、国民の口腔の健康増進に与える影響は大きいものと思われる。
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