Development of a novel root caries treatment by bacterial inactivation factor
| Project/Area Number |
15K11113
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
OHARA Naoko 岡山大学, 大学病院, 講師 (80301365)
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| Co-Investigator(Kenkyū-buntansha) |
吉山 昌宏 岡山大学, 医歯薬学総合研究科, 教授 (10201071)
大原 直也 岡山大学, 医歯薬学総合研究科, 教授 (70223930)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 根面う蝕 / う蝕誘発モデル / う蝕細菌 |
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| Outline of Final Research Achievements |
In this study an in vitro root caries induction model system was constructed to develop a new treatment for inhibition of progression of root caries. Using this model system, we investigated the influence on root caries progression bacteria dynamics of the carious lesion by strains and the culture conditions of cariogenic bacteria. The results showed that three Actinomyces species, A. naeslundii, A. viscosus, and A. israelii, possessed different characteristics on the pathology and the mechanisms of root caries progression.
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Report
(4 results)
Research Products
(7 results)
