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Analysis of mechanism for pro-inflammatory and anti-inflammatory balance and role of Th17 cells in pulpitis

Research Project

Project/Area Number 15K11115
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Conservative dentistry
Research InstitutionThe University of Tokushima

Principal Investigator

NAKANISHI Tadashi  徳島大学, 大学院医歯薬学研究部(歯学系), 准教授 (00217770)

Co-Investigator(Kenkyū-buntansha) 湯本 浩通  徳島大学, 大学院医歯薬学研究部(歯学系), 教授 (60284303)
細川 義隆  徳島大学, 病院, 講師 (90346601)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords歯髄炎 / 象牙芽細胞 / Th17 / 歯髄 / 炎症 / サイトカイン / IL-17 / ケモカイン
Outline of Final Research Achievements

The purpose of this study was to elucidate the role of Th17 cells in the pathogenesis of pulpitis, and thus we examined the effect of interleukin(IL)-17 on CCL20 production from KN-3 cells established as rat odontoblast-like cells.
IL-17 increased CCL-20 production from KN-3 cells exposed to IL-1. The treatment of IL-17 also enhanced the phosphorylation of mitogen-activated protein kinases (MAPKs) in IL-1 stimulated KN-3 cells. Moreover, epigallocatechin-3 gallate, a representative type of catechins, reduced CCL20 production from activated KN-3 cells.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (3 results)

All 2017 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Anti-inflammatory Effects of Catechin on Rat Odontoblastic Cells (KN-3)2017

    • Author(s)
      平尾功治、湯本浩通、細川由樹、蔵本 瞳、鷲尾絢子、中西 正、武川大輔、北村知昭、松尾敬志
    • Journal Title

      The Japanese Journal of Conservative Dentistry

      Volume: 60 Issue: 5 Pages: 235-244

    • DOI

      10.11471/shikahozon.60.235

    • NAID

      130006191168

    • ISSN
      0387-2343, 2188-0808
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Effect of interleukin-17A on CCL20 production from odontoblast-like cells.2017

    • Author(s)
      Tadashi Nakanishi, Daisuke Takegawa, Kouji Hirao, Hiromichi Yumoto, Yuki Hosokawa, Takashi Matsuo
    • Organizer
      95th General Session & Exhibition of the IADR
    • Place of Presentation
      San Francisco (USA)
    • Year and Date
      2017-03-22
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Interleukin-17がラット象牙芽細胞様細胞(KN-3)のCCL20産生に及ぼす影響2015

    • Author(s)
      中西 正、武川大輔、平尾功治、湯本浩通、細川由樹、松尾敬志
    • Organizer
      日本歯科保存学会 2015年度秋季学術大会(第143回)
    • Place of Presentation
      文京シビックホール(東京都・文京区)
    • Year and Date
      2015-11-12
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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