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Development of bioactive materials and improvement on long-term durability

Research Project

Project/Area Number 15K11124
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Conservative dentistry
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

ITO Shuichi  北海道医療大学, 歯学部, 准教授 (50382495)

Co-Investigator(Kenkyū-buntansha) 飯嶋 雅弘  北海道医療大学, 歯学部, 准教授 (20305915)
斎藤 隆史  北海道医療大学, 歯学部, 教授 (40265070)
齊藤 正人  北海道医療大学, 歯学部, 教授 (50337036)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords象牙質 / 再石灰化 / バイオアクティブ材料 / 接着性モノマー / 象牙質石灰化
Outline of Final Research Achievements

The adhesive restorative material is essential for dental treatment. However, there are some points to be improved in the material such as long-term durability. Recently, the development of adherent monomer, 4-MET linked with calcium (4-MET-Ca) were blended the one step bonding (HC). This study aims to develop MDP-Ca newly, and to investigate of new bonding material (MDCP) that MDP-Ca was blended into the all-in-one self-adhesive material comprising 4-META. MDCP formed excellent bonding layer, showed high adhesive ability compared to the control. MDCP was improved dissolution resistance and long-term durability of cured bonding material. Compared to the CMET, MDCP was no significant but showed superiority. It was suggested that MDP-Ca improved the adhesion strength in a different manner from 4-MET-Ca.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (25 results)

All 2018 2017 2016 2015

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (19 results) (of which Int'l Joint Research: 6 results,  Invited: 3 results) Book (1 results)

  • [Journal Article] 象牙質再石灰化を誘導する材料2017

    • Author(s)
      伊藤修一
    • Journal Title

      日本歯科保存誌

      Volume: 60 Pages: 267-269

    • NAID

      130006304465

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] S-PRGフィラー含有根管貼薬剤が根尖孔外に及ぼす影響に関するin vitroでの検討2017

    • Author(s)
      16.白井要,伊藤修一,中塚侑子,清水伸太郎,河野舞,斎藤隆史,長澤 敏行,古市 保志
    • Journal Title

      日本歯科保存誌

      Volume: 60 Pages: 69-77

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of single application of pastes containing ion-releasing particles on enamel demineralization2017

    • Author(s)
      15.Iijima M, Kawaguchi K Kawamura N, Ito S, Saito T, Mizoguchi I
    • Journal Title

      Dent Mater J

      Volume: 36 Pages: 461-468

    • NAID

      130005865139

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] CO2レーザー照射とグラスアイオノマーセメントによる象牙質の再石灰化2016

    • Author(s)
      飯嶋雅弘, 伊藤修一, 川村尚彦, 斎藤隆史, 溝口 到
    • Journal Title

      日本レーザー歯学会誌

      Volume: 27 Pages: 101-107

    • NAID

      130005290130

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Wear Characteristics and inhibition of enamael demineralization by resin-based coating materials2016

    • Author(s)
      Kawamura N, Iijima M, Ito S, Brantley WA, Alpati SB, Muguruma T, Kawaguchi K, Saito T, Mizoguchi I
    • Journal Title

      Eur J Oral Sci

      Volume: 125 Pages: 160-167

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] S-PRG フィラー溶出液が象牙芽細胞前駆細胞に与える影響2018

    • Author(s)
      1.油井知雄,伊藤修一,斎藤 隆史. S-PRG フィラー溶出液が象牙芽細胞前駆細胞に与える影響
    • Organizer
      第3回生体機能性材料S-PRGフィラー研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] In vitro Effect of S-PRG containing paste in dentin reminelization2017

    • Author(s)
      Iijima M, Kawaguchi K, Kawamura N, Ishikawa R, Ito S, Saito T, Mizoguchi I
    • Organizer
      94thIADR
    • Place of Presentation
      Moscone Center サンフランシスコ
    • Year and Date
      2017-03-22
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] フッ化物含有知覚過敏抑制材料による象牙質再石灰化の検討2017

    • Author(s)
      11.松田康裕,奥山克史,山本洋子,泉川昌宣,油井知雄,伊藤 修一,林美加子,斎藤隆史
    • Organizer
      第15回日本再生歯科医学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] S-PRGフィラー溶出液が象牙芽細胞前駆細胞に与える影響2017

    • Author(s)
      油井知雄,泉川昌宣,松田康裕,伊藤修一,斎藤隆史
    • Organizer
      第147回日本歯科保存学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Possibility of bioactive materials containing2016

    • Author(s)
      Ito S
    • Organizer
      International Dental Materials Congress 2016
    • Place of Presentation
      ストーンホテル、バリ
    • Year and Date
      2016-11-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Demineralize prevention of dentin with S-PRG varnish via automatic pH-cycling2016

    • Author(s)
      Matsuda Y, Okuyama K, Yamamoto H, Ooki S, Izumikawa M, Yui T, Ito S, Sano H , Saito T
    • Organizer
      146th scientific meeting of the Korean Academy of Conservative Dentistry
    • Place of Presentation
      The K Hotel ソウル
    • Year and Date
      2016-10-21
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] ホワイトニング歯質に与える影響2016

    • Author(s)
      伊藤修一
    • Organizer
      第27回日本歯科審美学会
    • Place of Presentation
      京王プラザホテル札幌
    • Year and Date
      2016-08-27
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Wear Characteristics of Resin-based Coating Materials2016

    • Author(s)
      KAWAMURA N, IIJIMA M, KAWAGUCHI K, ALAPATI SB, BRANTLEY WA, ITO S, MUGURUMA T, SAITO T MIZOGUCHI I
    • Organizer
      94thIADR
    • Place of Presentation
      COEXコンベンションセンター
    • Year and Date
      2016-06-22
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Micro-XRD Investigation of EndoSequence and MTA Root-Repair Material Setting Reactions2016

    • Author(s)
      ALAPATI SB, IIJIMA M,BRANTLEY WA, ITO S, MUGURUMA T, SAITO T, MIZOGUCHI I
    • Organizer
      94thIADR
    • Place of Presentation
      COEXコンベンションセンター
    • Year and Date
      2016-06-22
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] In vitro Investigation of Nanoproperties at Dentin-Pulp Capping Material Interface2016

    • Author(s)
      ALAPATI SB, IIJIMA M, BRANTLEY WA, ITO S, MUGURUMA T, SAITO T, MIZOGUCHI I
    • Organizer
      94thIADR
    • Place of Presentation
      COEXコンベンションセンター
    • Year and Date
      2016-06-22
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] フッ化物含有知覚過敏抑制材による象牙質表面の脱灰抑制効果2016

    • Author(s)
      松田康裕、奥山克史、山本洋子、大木彩子、泉川昌宣、油井知雄、伊藤修一、佐野英彦、斎藤隆史
    • Organizer
      第144回日本歯科保存学会
    • Place of Presentation
      栃木県総合文化センター
    • Year and Date
      2016-06-09
    • Related Report
      2016 Research-status Report
  • [Presentation] 新規バイオアクティブセメントのイオン放出および生物学的性質の比較検討2016

    • Author(s)
      近藤有紀,伊藤修一,植原 治,倉重圭史,斎藤隆史,齊藤正人
    • Organizer
      第144回日本歯科保存学会
    • Place of Presentation
      栃木県総合文化センター
    • Year and Date
      2016-06-09
    • Related Report
      2016 Research-status Report
  • [Presentation] ボンディング材における接着性モノマー添加による象牙質接着性に対する影響2016

    • Author(s)
      藤田裕介,伊藤修一,村井雄司,近藤有紀,斎藤隆史,齊藤正人
    • Organizer
      第54回日本小児歯科学会
    • Place of Presentation
      東京ドームホテル
    • Year and Date
      2016-05-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 新規バイオアクティブセメントのバイオフィルム形成抑制能および細胞増殖活性に対する影響2016

    • Author(s)
      近藤有紀,伊藤修一, 佐藤夕紀,植原 治,倉重圭史,斎藤隆史,齊藤正人
    • Organizer
      第54回日本小児歯科学会
    • Place of Presentation
      東京ドームホテル
    • Year and Date
      2016-05-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 予防的保存修復治療の考え方2016

    • Author(s)
      伊藤修一
    • Organizer
      第13回顕微鏡歯科学会
    • Place of Presentation
      ホテルニューオータニイン札幌
    • Year and Date
      2016-04-23
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] イオン徐放性歯磨剤のエナメル質着色に対する影響2015

    • Author(s)
      尾形美和、伊藤修一、斎藤隆史
    • Organizer
      第26回日本審美歯科学会
    • Place of Presentation
      東京歯科大学
    • Year and Date
      2015-11-22
    • Related Report
      2015 Research-status Report
  • [Presentation] S-PRGフィラー含有根管貼薬剤のCandida albicansに対する効果について2015

    • Author(s)
      白井要、植原治、伊藤修一、斎藤隆史、古市保志
    • Organizer
      第142回日本歯科保存学会
    • Place of Presentation
      北九州国際会議場
    • Year and Date
      2015-06-25
    • Related Report
      2015 Research-status Report
  • [Presentation] CO2レーザー照射とフッ化物塗布を併用したエナメル質の脱灰抑制2015

    • Author(s)
      飯嶋雅弘、伊藤修一、斎藤隆史、溝口到
    • Organizer
      第27回日本レーザー歯学会
    • Place of Presentation
      北海道自治労会館
    • Year and Date
      2015-06-07
    • Related Report
      2015 Research-status Report
  • [Presentation] 新規バイオアクティブセメントの物理化学的特性について2015

    • Author(s)
      近藤有紀、伊藤修一、高田一江、植原治、倉重圭史、斎藤隆史、齊藤正人
    • Organizer
      第53回日本小児歯科学会
    • Place of Presentation
      広島国際会議場
    • Year and Date
      2015-05-21
    • Related Report
      2015 Research-status Report
  • [Book] 接着歯学2015

    • Author(s)
      伊藤修一、斎藤隆史
    • Total Pages
      186
    • Publisher
      医歯薬出版
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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