| Project/Area Number |
15K11125
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
川上 智史 北海道医療大学, 歯学部, 教授 (00169682)
舞田 健夫 北海道医療大学, 歯学部, 教授 (40229282)
安彦 善裕 北海道医療大学, 歯学部, 教授 (90260819)
齊藤 正人 北海道医療大学, 歯学部, 教授 (50337036)
植原 治 北海道医療大学, 歯学部, 助教 (00709248)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ホップ / キサントフモール / S. mutans |
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| Outline of Final Research Achievements |
Hops are safe for living bodies and have antimicrobial and anti-inflammatory effects on oral bacteria which cause dental plaque, and anti-dental plaque action can be expected by their combined action. However, there have been reports on antimicrobial activity against various gram-positive bacteria by components of hops, but how hops act on caries pathogenic bacteria S. mutans and periodontal pathogenic bacteria P. gingivalis There is no report. In this study, the influence of antibacterial component (xanthohumol) of hops on S. mutans, P. gingivalis and gingival epithelial cells was evaluated. It was suggested that xanthohumol could inhibit iron uptake necessary for the growth of P. gingivalis at a concentration not showing cytotoxicity to gingival epithelial cells.
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