| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
This study carried out MTA direct capping experiments to clarify effects of MTA on the infected dental pulp and discussed the results from the viewpoint of stem cell biology. The infection model exposed to the oral environment after preparing the drilled cavity in the mouse molar and the non-infection model without remaining exposed after operation were sealed with MTA or calcium hydroxide cement (CH) in addition to glass ionomer cement (GI) as a control. Pulpal healing process was analyzed by HE staining and immunohistochemistry in the paraffin sections. The MTA group showed good healing process compared with the CH group. The findings suggest that MTA is useful as a substance for activating biofunction for infected dental pulp. However, the validity of the current experimental design remains to be verified in terms of the infection period, since the infected dental pulp was healed even in the GI group.
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