| Project/Area Number |
15K11142
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
畠山 純子 福岡歯科大学, 口腔歯学部, 助教 (50374947)
阿南 壽 福岡歯科大学, 口腔歯学部, 教授 (80158732)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | アメロゲニン / 生体活性ガラス / 骨再生 / 骨欠損窩洞 / 骨形成 |
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| Outline of Final Research Achievements |
Animal experiments were conducted to examine the development of an effective hard tissue regeneration therapy by using amelogenin (AME) as a regeneration promoting factor and bioactive glass (BAG) as a scaffold in combination. A bone defect cavity was formed in the rat skull and a sample was placed there to evaluate the amount and condition of hard tissue formation over time. As a result of quantitative analysis, compared to the AME group and the BAG group, the AME + BAG group tended to show more hard tissue formation, but no significant difference was recognized. Histologically, in the AME + BAG group, a thick fibrous hard tissues were observed throughout the cavity at 8 weeks after surgery.
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| Academic Significance and Societal Importance of the Research Achievements |
再生療法の場においてAMEもBAGもその有用性が報告されており、いくつかの商品が歯科再生療法の現場でも使用されている。しかしながら、これらの材料の作用機序についてはいまだ不明な点も残っており、両者を併用した場合の効果についてもいまだ賛否両論あり、最終的な結論は出ていない。今回、骨誘導因子としてAMEとBAGを応用し、骨髄腔の存在しない頭蓋骨欠損部での実験結果を検討することで、その作用機序について詳しく解析するとともに、両者を併用することで、消失した硬組織のより効率的な再生法の確立を目指している。
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