| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
In this project, in vitro and in vivo tests were performed to evaluate the antimicrobial chemotherapy utilizing photo-irradiated polyphenols. Streptococcus mutans biofilm was treated with the technique using caffeic acid, chlorogenic acid and proanthocyanidin as a representative polyphenol. The results showed that the technique using caffeic acid exerted the highest bactericidal activity. In vivo study where oral mucosal irritation potential of the antimicrobial technique was evaluated demonstrated that it exerted slight irritation potential. Therefore, in order to apply this technique to clinical dentistry, it is suggested that future studies should evaluate the bactericidal effect (benefit) and the oral mucosal irritation potential (risk) more in detail.
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